- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06155851
Prevalence of Hiatus Hernia in Gastro-Esophageal Reflux Disease Patients Underwent Upper Endoscopy
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Gastro-esophageal reflux disease (GERD) is a common problem for which patients seek care from a broad array of primary care providers, medical sub-specialists, and surgeons.
It is estimated that 10 to 20 percent of people in Western countries have GERD, when defined as heartburn or regurgitation at least once a week. (Chapelle, et al. 2021)
The practice guidelines for GERD recommend diagnostic testing in the presence of alarm symptoms, which include dysphagia, odynophagia, weight loss, gastrointestinal bleeding, and anemia.
A detailed history of the pattern, severity, and duration of alarm symptoms is essential. (Katz, et al., 2022) Hiatus hernia refers to condition in which elements of the abdominal cavity, most commonly the stomach, herniate through the esophageal hiatus into the mediastinum.
Hiatus hernia is a frequent finding during upper gastrointestinal endoscopy. Type I hiatal hernia is the sliding hiatal hernia, which accounts for more than 95% of all hiatal hernias with the remaining 5% being Para-esophageal hiatus hernias (Kotekar, et al 2021)
Endoscopy is a common diagnostic tool in the evaluation of patients with upper gastrointestinal pathology, specifically gastroesophageal reflux disease (GERD) and hiatal hernia.
The relationship between these two disease processes are relatively intertwined and have clinical significance given the fact patients with hiatal hernia may be more likely to have acid reflux and there is a close relationship with hiatal hernia size and incidence of reflux disease. (Gomaa, et al 2022) Worldwide, it is believed that the relation between hiatus hernia and gastro-esophageal reflux disease (GERD) have varied considerably.
In our locality the prevalence of hiatal hernia in GERD patients and the effect of hiatal hernia on the severity of GERD symptoms is unknown.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Esraa Ibrahim abo el ela, Resident
- Phone Number: 01096265575
- Email: asoraibrahim8@gmail.com
Study Contact Backup
- Name: Mohamed Omar Abdelmalek, Prof
- Phone Number: 01007343214
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Aged 18 years or older, Patients with GERD symptoms who don't respond to PPI therapy (8 weeks ) or cases with alarm symptoms (dysphagia, anemia ,vomiting , weight loss , GI bleeding , onset of symptoms in old age ,..etc)
Exclusion Criteria:
- Complete PPI responder. Patient with any contraindication for endoscopy . Refusal of participation
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
To study the prevalence of hiatus hernia in GERD patients underwent upper endoscopy To study the effect of hiatus hernia on the severity of GERD symptoms.
Time Frame: prospective cohort syudy_ up to 1 year
|
To study the prevalence of hiatus hernia in GERD patients underwent upper endoscopy To study the effect of hiatus hernia on the severity of GERD symptoms.
|
prospective cohort syudy_ up to 1 year
|
Collaborators and Investigators
Sponsor
Publications and helpful links
General Publications
- Levin JG, Seidman JG. Selective packaging of host tRNA's by murine leukemia virus particles does not require genomic RNA. J Virol. 1979 Jan;29(1):328-35. doi: 10.1128/JVI.29.1.328-335.1979.
- Daraz B, Piela A. [Treatment and prevention of EPH-gestosis]. Pieleg Polozna. 1978;(5):7-8. No abstract available. Polish.
- Kromer W, Freundt KJ. [In vitro inhibition of oxidative N-demethylation with carbon disulfide]. Arzneimittelforschung. 1976 Feb;26(2):189-94. German.
- Newton JM, Razzo RN. Proceedings: The influence of formulation variables on the in vitro release of drug from hard gelatin capsules. J Pharm Pharmacol. 1975 Dec;27 Suppl?-2:79P. No abstract available.
- Herold G, Stephan B, Menzel T. [The behavior of bioelements during long-term parenteral feeding]. Infusionsther Klin Ernahr. 1979 Apr;6(2):105-10. German.
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Prevalence of Hiatus Hernia in
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Hiatus Hernia
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University of ZurichCompleted
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Minia UniversityCompleted
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University of NebraskaLifeCellCompletedHiatal Hernia | Esophageal Hernia | Hernia, Esophageal | Hernia, Paraesophageal | Paraesophageal Hiatal Hernia | Sliding Esophageal Hernia | Sliding Hiatal HerniaUnited States
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Advanced Medical Solutions Ltd.CompletedInguinal Hernia | Hernia | Femoral Hernia | Groin HerniaUnited States
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Medtronic - MITGCompletedInguinal Hernia | Ventral HerniaUnited States
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Mette Astrup MadsenCompletedInguinal Hernia | Femoral HerniaDenmark
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W.L.Gore & AssociatesRecruitingHernia, Hiatal | Hernia, Diaphragmatic | Hernia, Ventral | Incisional HerniaUnited States
-
Hobart HarrisWithdrawnHernia | Ventral Hernia | Abdominal Hernia
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Anne Arundel Health System Research InstituteMedtronic - MITGCompletedGrade I Ventral Hernia | Grade II Ventral HerniaUnited States
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Konya Meram State HospitalCompletedInguinal Hernia | Ventral Hernia | General SurgeryTurkey
Clinical Trials on Upper Endoscopy
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Technical University of MunichRotkreuzklinikum München gGmbH; Klinikum Freising; Klinikum Landshut-Achdorf; Städtisches... and other collaboratorsCompletedEndoscopic Diagnosis in EsophagusGermany
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Unidade Local De Saúde Do Norte AlentejanoNOVA Medical SchoolRecruiting
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Assiut UniversityNot yet recruitingUpper Gastrointestinal Disorder
-
Chinese University of Hong KongRecruitingEsophageal Cancer | Microbial ColonizationHong Kong
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Sohag UniversityRecruitingHelicobacter Pylori InfectionEgypt
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Sohag UniversityCompletedAll Patients With Upper GIT Symptoms and Underwent Upper EndoscopyEgypt
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Sohag UniversityRecruitingUpper Gastrointestinal Variceal Bleeding in Cirrhotic PatientsEgypt
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Sana Klinikum OffenbachCompleted
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Johns Hopkins UniversityEthicon, Inc.WithdrawnEsophageal and Gastric VaricesUnited States
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Zagazig UniversityRecruiting