The Value of TOI in Evaluating Renal Function Damage in Hypertensive Emergency Patients

The Value of Smartphone-based Optical Blood Spectrum Imaging (TOI) in Evaluating Renal Function Damage in Hypertensive Emergency Patients

TOI was used to measure heart rate, respiration, blood pressure, heart rate variability and psychological stress. At the same time, the patient's urine protein, creatinine, urea nitrogen and other indicators were detected. According to different renal function, they were divided into observation group and control group, and 100 general inpatients with renal insufficiency were selected as positive control group. The relationship between TOI composite index and renal function in hypertensive emergency patients was compared.

Study Overview

• Status: Not yet recruiting
• Conditions: Hypertensive Emergency
• Intervention / Treatment: Other: The relationship between TOI composite index and renal function in hypertensive emergency patients was compared

Detailed Description

TOI technique was used to measure the heart rate, respiration, blood pressure, heart rate variability, psychological pressure, etc. At the same time, the urine protein, creatinine, urea nitrogen and other results of these patients were measured. According to the different renal function, they were divided into observation group and control group, and 100 ordinary hospitalized patients with renal insufficiency were selected as positive control group. The relationship between TOI composite index and renal function in hypertensive emergency patients was compared. The data management platform provides intelligent management of patients' out-of-hospital follow-up, and the dynamic physiological indicators and psychological assessment data of patients are mastered through the hospital port, so as to provide telemedicine guidance for patients, so as to improve the prognosis of hypertensive emergency patients.

• Study Type: Observational
• Enrollment (Estimated): 300

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Probability Sample

Study Population

Patients hospitalized for acute hypertension from January 2022 to December 2024 with onset time <48 hours and blood pressure measured by standard sphygmomanometer: Systolic blood pressure (SBP)>180mmHg and/or diastolic blood pressure (DBP)>120mmHg, age >18 years old, gender, stable vital signs, good compliance, complete and reliable medical records.

Description

Inclusion Criteria:

• Systolic blood pressure (SBP)>180mmHg
• Diastolic blood pressure (DBP)>120mmHg

Exclusion Criteria:

• Severe head and facial skin injury
• Cerebral hemorrhage or severe shock after admission
• Patients who insist on refusing to participate in this clinical tria
• Patients who could not participate in the study for other reasons.

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Control group
Observation group	Other: The relationship between TOI composite index and renal function in hypertensive emergency patients was compared; The relationship between TOI composite index and renal function in hypertensive emergency patients was compared. The data management platform provides intelligent management of patients' out-of-hospital follow-up, and the dynamic physiological indicators and psychological assessment data of patients are mastered through the hospital port, so as to provide telemedicine guidance for patients, so as to improve the prognosis of hypertensive emergency patients.
Positive control group

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
creatinine	creatinine levels of enrolled patients	2023-12-01 to 2024-12-31
urea nitrogen	urea nitrogen levels of enrolled patients	2023-12-01 to 2024-12-31
blood pressure	Both systolic and diastolic Blood Pressure levels of enrolled patients	2023-12-01 to 2024-12-31

Collaborators and Investigators

• Sponsor: The Affiliated Hospital of Hangzhou Normal University

Study record dates

Study Major Dates

• Study Start (Estimated): February 1, 2024
• Primary Completion (Estimated): December 31, 2024
• Study Completion (Estimated): December 31, 2024

Study Registration Dates

• First Submitted: January 2, 2024
• First Submitted That Met QC Criteria: January 2, 2024
• First Posted (Actual): January 11, 2024

Study Record Updates

• Last Update Posted (Actual): January 22, 2024
• Last Update Submitted That Met QC Criteria: January 19, 2024
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Cardiovascular Diseases; Vascular Diseases; Disease Attributes; Hypertension; Emergencies; Hypertension, Malignant
• Other Study ID Numbers: AH-2023-001

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No