Perioperative Factors and Early Postoperative Kidney Graft Function Recovery

February 27, 2024 updated by: Min Suk Chae, Seoul St. Mary's Hospital

Analysis of Perioperative Factors Affecting Early Postoperative Kidney Graft Function Recovery in Patients Undergoing Living Kidney Transplant Surgery

Divided into two groups based on acute kidney injury: non-acute kidney injury group vs. non-acute kidney injury group. Acute kidney injury group, Acute Kidney Injury Network (AKIN), Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease (RIFLE), or Kidney Disease: Improving Global Outcomes (KDIGO) I would like to divide it according to the definition. After testing the normal distribution of patients, donors, grafts, types of immunosuppressants, surgery/anesthesia factors, and blood test findings between the two groups through the Shapiro-Wilk test, continuous data was tested using the student t-test or Mann-Whitney U test. Sizes are compared using , and categorical data is compared with proportions using the χ2 test or Fisher's exact test. Analysis of factors related to acute kidney injury will be performed through univariate and multivariate logistic regression analysis.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

539

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

Adult patients aged 19 or older who underwent kidney transplant surgery in the operating room of Seoul St. Mary's Hospital from January 1, 2016 to March 28, 2022.

Description

Inclusion Criteria:

  • Adult patients aged 19 years or older who underwent kidney transplant surgery in the operating room

Exclusion Criteria:

  • Pediatric patients under 19 years of age
  • Patients with multiple organ transplants, including kidney transplants
  • Patients undergoing re-kidney transplant surgery
  • Patient examination findings missing from electronic medical record

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
nonischemic
ischemic
Procedure: Remote ischemic conditioning
Remote ischemic condition

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Troponin I
Time Frame: up to 24 hour postoperatively
Troponin I difference in two groups
up to 24 hour postoperatively

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Troponin T
Time Frame: up to 24 hour postoperatively
Troponin T difference in two groups
up to 24 hour postoperatively
QTc interval
Time Frame: up to 24 hour postoperatively
OTc interval difference in two groups
up to 24 hour postoperatively

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Seoul St. Mary's Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2020

Primary Completion (Actual)

March 14, 2022

Study Completion (Actual)

March 14, 2022

Study Registration Dates

First Submitted

February 16, 2024

First Submitted That Met QC Criteria

February 25, 2024

First Posted (Actual)

February 28, 2024

Study Record Updates

Last Update Posted (Actual)

February 29, 2024

Last Update Submitted That Met QC Criteria

February 27, 2024

Last Verified

February 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • KC22RISI0395

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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