Effects of Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety in Elderly Patients
April 9, 2024 updated by: Weidong Mi, Chinese PLA General Hospital
Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of volatile anaesthetics on the incidence of postoperative depression and anxiety among elderly patients.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Studies have suggested volatile anaesthetics may alleviate depression and anxiety in patients. However, there is a paucity of research in this area. The investigatorswanted to determine the association between volatile anaesthetics and depression/anxiety in elderly patients within 7 days after surgery.
This study retrospectively analysed data from a prospective database of patients aged 65 and above who underwent non-cardiac, non-neurosurgical elective surgery in 18 tertiary hospitals across 10 provinces in China. Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic. Binary logistic regression analyses were conducted, and propensity score-matching (PSM) and subgroup analyses were also applied.
Study Type
Observational
Enrollment (Actual)
8000
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Beijing
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Beijing, Beijing, China
- Chinese PLA General Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Older Adult
Accepts Healthy Volunteers
No
Sampling Method
Probability Sample
Study Population
Elderly patients (aged ≥ 65 years) who completed the anxiety and depression assessment on the seventh day after the elective noncardiac, non-neurosurgical surgery were included in this study.
Description
Inclusion Criteria:
Geriatric surgical patients ≥65 years old Non-selective cardiac surgery Non-neurosurgical
Exclusion Criteria:
- underwent reoperation within 7 days
- ASA classification of Ⅳ or above
- history of serious mental illness or long-term use of psychotropic drugs
- patients either died or were transferred to the intensive care unit within 7 days of the surgery
- subjects with missing covariate data
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
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volatile anaesthetic (sevoflurane, isoflurane, desflurane）
Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.
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Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.
Other Names:
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control
Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Depression
Time Frame: Depression within 7 days of surgery
|
Primary outcomes were depression Patient Health Questionnaire 9 (PHQ-9).The PHQ-9 is a nine-item questionnaire for screening on the presence of depressive symptoms and monitoring depression severity.
Items were scored on a four-point scale with total scores ranging from zero to twenty-seven.
Scores were defined as: ≥5 mild, ≥10 moderate, and ≥15 severe level of depression.
The recommended screening cutoff was ≥10, corresponding with at least a moderate level of depression.
The higher the score, the worse the situation.
The total score ranges from 0 to 27, and higher scores indicate more depressive symptoms.
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Depression within 7 days of surgery
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Anxiety
Time Frame: Anxiety within 7 days of surgery
|
The GAD-7 is a seven-item questionnaire for screening on the presence of generalized anxiety disorder and assessing its severity.
Items were scored on a four-point scale with total scores ranging from zero to twenty-one.
Scores were defined as: ≥5 mild, ≥10 moderate, and ≥15 severe anxiety.
The recommended screening cutoff was ≥10, corresponding with at least a moderate level of anxiety.
Higher scores mean more anxiety.
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Anxiety within 7 days of surgery
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Study Chair: Weidong Mi, PhD, Chinese PLA General Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
April 1, 2020
Primary Completion (Actual)
October 31, 2021
Study Completion (Actual)
April 30, 2022
Study Registration Dates
First Submitted
March 6, 2024
First Submitted That Met QC Criteria
March 6, 2024
First Posted (Actual)
March 13, 2024
Study Record Updates
Last Update Posted (Actual)
April 10, 2024
Last Update Submitted That Met QC Criteria
April 9, 2024
Last Verified
April 1, 2024
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- PLAGH-DA-002
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
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