Arterial Blood Pressure and Cardiac Arrest (ABaCAS)

To describe and measure diastolic and systolic femoral arterial pressure during medical cardiac arrest.

To define baseline measures. To describe and measure arterial blood pressure after placement of an ITD device.

To observe the diastolic pressure immediately prior to return of spontaneous circulation.

To quantify and describe the effects of intravenous adrenaline on arterial blood pressure in cardiac arrest.

Study Overview

• Status: Withdrawn
• Conditions: Cardiac Arrest
• Intervention / Treatment: Device: impedance threshold device

Detailed Description

Cardiac arrest is a complex disorder whose outcome is reliant on a huge number of factors. Moreover, many interventions are time critical, therefore an intervention that may be lifesaving if given early, may have no benefit if instigated further in the disease course. For these reasons' studies involving cardiac arrest are incredibly difficult to carry out and interpret. Many of the interventions carried out during cardiac arrest are aimed at improving blood pressure and thereby increasing the amount of blood and oxygen delivered to the myocardium in the hopes of achieving a return of spontaneous circulation (ROSC). However current data on what a 'normal' blood pressure, based largely upon non-invasive measurement, during cardiac arrest is severely limited, making comparison and evaluation of interventions extremely difficult. This provides the basis for this study in order to prospectively collate and describe data from invasive blood pressure monitoring during adult, medical cardiac arrest in the pre-hospital environment.

3. Research Question/Aim(s) To measure and describe femoral arterial pressure during cardiac arrest with mechanical CPR by a LUCAS device. 3.1 Objectives Primary objective To quantify and describe baseline arterial systolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting. This will be defined as a line of best fit for systolic blood pressure superimposed on the arterial trace during a 3 minute period.

Secondary Objectives

• To quantify and describe baseline arterial diastolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting. This will be defined as a line of best fit for diastolic blood pressure superimposed on the arterial trace during a 3 minute period.
• To quantify and describe arterial blood pressure after the placement of an ITD device over a 3 minute period.
• To quantify and describe the effect of intravenous adrenaline on blood pressure as administered in line with ALS guidelines (every 3-5 mins) in adult patients in cardiac arrest.
• To document the diastolic blood pressure of those patients that achieve return of spontaneous circulation (ROSC) following out of hospital cardiac arrest.

• Study Type: Observational

Contacts and Locations

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Adult patients (18+) suffering an out of hospital cardiac arrest (OHCA) by a presumed medical cause that have been deemed suitable to attempt resuscitation of.

All individuals will be considered for inclusion in this study regardless of age, disability, gender reassignment, marriage, and civil partnership, pregnancy and maternity, race, religion and belief, sex, and sexual orientation except where the study inclusion and exclusion criteria EXPLICITLY state otherwise.

Description

Inclusion Criteria:

• Adult patients (≥18years) in medical cardiac arrest
• Deemed suitable to attempt resuscitation.

Exclusion Criteria:

• Prisoners
• <18years
• Pregnancy
• Traumatic cardiac arrest
• Arrest caused by hypovolaemia, tension or tamponade as determined by the clinical team on scene
• Inability to secure a patent airway.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
adult cardiac arrest; blood pressure measurement pre and post impedance threshold device placement	Device: impedance threshold device; impedance threshold device (ResQPOD, Zoll) applied to airway

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
systolic femoral invasive blood pressure	3 mins average with CPR by LUCAS device

Secondary Outcome Measures

Outcome Measure	Time Frame
femoral diastolic pressure	3 mins average with CPR by LUCAS device
femoral arterial pressure, both systolic and diastolic	3 mins average post placement of ICD device

Collaborators and Investigators

• Sponsor: Manchester University NHS Foundation Trust
• Collaborators: North West Ambulance Service nhs foundation trust

Study record dates

Study Major Dates

• Study Start (Estimated): September 1, 2024
• Primary Completion (Estimated): December 1, 2024
• Study Completion (Estimated): June 1, 2025

Study Registration Dates

• First Submitted: May 30, 2024
• First Submitted That Met QC Criteria: May 30, 2024
• First Posted (Actual): June 5, 2024

Study Record Updates

• Last Update Posted (Estimated): September 25, 2025
• Last Update Submitted That Met QC Criteria: September 23, 2025
• Last Verified: September 1, 2025

More Information

Terms related to this study

• Keywords: blood pressure; cardiac arrest; impedance threshold device
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Heart Diseases; Heart Arrest
• Other Study ID Numbers: B01830

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: Yes
• product manufactured in and exported from the U.S.: No