Effects of Combining Different Exercise Modes With CPT on Vascular Function and Sleep Quality in Female University Students With SD

Effects of Combining Different Exercise Modes With Cold Pressor Test on Vascular Function and Sleep Quality in Female University Students With Sleep Disorders

Fourteen female college students with sleep disorders (SD) and fourteen with good sleep status were recruited, divided into sleep disorder group (SDG) and control group (CG). Both groups underwent moderate-intensity continuous training (MICT), high-intensity interval training (HIIT), and sprint interval training (SIT). Immediately after exercise, Cold Pressor Test (CPT) was administered, vascular indicators were measured immediately and 30 minutes later. The next day after exercise, participants completed the Pittsburgh sleep quality index (PSQI). Each exercise mode had a washout period of at least 7 days.

Study Overview

• Status: Completed
• Conditions: Vascular Function; Sleep Quality
• Intervention / Treatment: Behavioral: MICT + CPT, HIIT + CPT, SIT + CPT

Detailed Description

Both SDG and CG underwent HIIT, MICT, and SIT interventions. After the exercise, a CPT was conducted, and vascular indicators were immediately measured at the end of the intervention. Another measurement was taken 30 minutes after the intervention. The exercise was performed on a power bike, with the requirement to maintain a pedaling frequency of 60 rpm. The exercise protocols for HIIT, MICT, and SIT were designed with equal exercise volume. The HIIT protocol consisted of 4 sets of 4 minutes at 85% maximal oxygen uptake data (VO2max), interspersed with 3 minutes at 50% VO2max. The MICT protocol involved continuous pedaling at 60% VO2max for 32 minutes. The SIT protocol included 6 sets of 30-second all-out sprints (100% VO2max) with 4.5 minutes of recovery at 60% VO2max between each sprint. There was a minimum of 7 days between each exercise mode as a washout period. The PSQI questionnaire was completed the day after each intervention upon waking up.

• Study Type: Interventional
• Enrollment (Actual): 28
• Phase: Not Applicable

Contacts and Locations

Study Locations

• China
  • Beijing, China
    • School of Sports Medicine and Rehabilitation, Beijing Sport University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Female university students aged between 18 and 30 years old
• Body Mass Index (BMI) between 18.5~24.0 kg/m2
• Presence of SD (PSQI > 8 points) or good sleep quality (PSQI ≤ 7 points)
• Not taking medications that affect sleep
• No cardiovascular diseases
• No regular exercise habits or specialized training but possessing the ability to complete the exercise program

Exclusion Criteria:

• Severe organic diseases such as heart, kidney, etc
• Metabolic diseases such as diabetes, etc.
• Taking medications that affect sleep (including drugs that promote or interfere with sleep)
• Permanent and severe exercise dysfunction
• Participation in other experiments

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Non-Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Control group	Behavioral: MICT + CPT, HIIT + CPT, SIT + CPT; Single acute intervention, each exercise mode had a washout period of at least 7 days.
Experimental: sleep disorder group	Behavioral: MICT + CPT, HIIT + CPT, SIT + CPT; Single acute intervention, each exercise mode had a washout period of at least 7 days.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pittsburgh Sleep Quality Index	The change of Pittsburgh Sleep Quality Index (PSQI) before and after the intervention, Pittsburgh Sleep Quality Index include: specifically PSQI total score, sleep quality, sleep latency, sleep duration, sleep efficiency, sleep disturbances, and daytime functioning.	The next morning following each intervention, within 24 hours post-intervention
Ankle-brachial pulse wave velocity (baPWV)	The change of baPWV before and after intervention.	Immediately after each intervention and 30 minutes later.
Ankle-brachial index (ABI)	The change of ABI before and after intervention.	Immediately after each intervention and 30 minutes later.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Blood pressure	The change of blood pressure before and after intervention.	Immediately after each intervention and 30 minutes later.

Collaborators and Investigators

• Sponsor: Beijing Sport University

Study record dates

Study Major Dates

• Study Start (Actual): August 1, 2022
• Primary Completion (Actual): November 30, 2022
• Study Completion (Actual): December 31, 2022

Study Registration Dates

• First Submitted: June 23, 2024
• First Submitted That Met QC Criteria: July 1, 2024
• First Posted (Actual): July 3, 2024

Study Record Updates

• Last Update Posted (Actual): July 3, 2024
• Last Update Submitted That Met QC Criteria: July 1, 2024
• Last Verified: June 1, 2024

More Information

Terms related to this study

• Keywords: exercise; vascular function; sleep disorders; cold pressor test
• Additional Relevant MeSH Terms: Mental Disorders; Nervous System Diseases; Neurologic Manifestations; Sleep Wake Disorders
• Other Study ID Numbers: EOCDEMWCPTOVFASQIFUSWSD

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No