Dairy and Vegan Cheese: Effect on Satiety and Blood Glucose

Sensory, Satiating and Glycaemic Characteristics of Cheese and Non-dairy Alternative Products to Cheese

The project will consist of two studies. One study will explore the satiating properties of dairy cheese and its dairy-free substitute when consumed ad libidum, and another study will investigate their effects on postprandial glycemia. Both studies will involve healthy young adults. The secondary outcomes of these studies will be food sensory characteristics, diet-induced thermogenesis, subjective feeling of fatigue and energy, gastrointestinal comfort level, and food intake. The proposed project results will help to better understand the health properties of the cheese and its dairy-free substitute.

Study Overview

• Status: Recruiting
• Conditions: Blood Glucose; Satiety Response
• Intervention / Treatment: Other: Food

• Study Type: Interventional
• Enrollment (Estimated): 52
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Bohdan Luhovyy, PhD; Phone Number: 902221380; Email: Bohdan.Luhovyy@msvu.ca

Study Locations

• Canada
  • Nova Scotia
    • Halifax, Nova Scotia, Canada, B3M 2J6
      • Recruiting
      • Mount Saint Vincent University
      • Contact: Bohdan Luhovyy, PhD; Phone Number: 902-457-6256; Email: bohdan.luhovyy@msvu.ca

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Young healthy adults

Exclusion Criteria:

• Breakfast skipper
• Smoker (including e-cigarettes) / cannabis consumer
• Be underweight, overweight or obese
• Have chronic diseases, including diabetes
• Taking certain medication
• Have lactose intolerance, food allergies or gastrointestinal disorders (e.g., irritable bowel syndrome, or others).

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Dairy; A food containing dairy cheese	Other: Food; Food
Experimental: Non-Dairy; A food containing vegan alternative to cheese	Other: Food; Food
Experimental: Conrtol; A control treatment in the form of food	Other: Food; Food

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Satiety	The components of average subjective appetite including desire to eat, hunger, fullness, and a prospective food consumption measured with 100mm visual analogue scales.	0-120 minutes
Blood glucose	The concentrations of blood glucose	0-120 minutes
Insulin	The concentrations of insulin	0-120 minutes
Food intake	Energy intake with an ad libitum meal at 120 minutes	0 minutes, 120 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Energy and Fatigue	Subjective perception of feeling energetic and fatigue	0-120 minutes
Gastrointestinal comfort	The subjective feeling of wellness and gastrointestinal discomfort parameters including the feeling of nausea, stomach cramps, flatulency, diarrhea and a subjective feeling of wellness, each measured with 100mm visual analogue scales.	0-120 minutes
Diet-induced thermogenesis	Indirect calorimetry	0-120 minutes
Sensory characteristics	The perception of pleasantness of the treatments (0 minutes) and a test meal (at 120 minutes) will be measured with 9-point hedonic and 100mm visual analogue scales.	0 minutes, 120 minutes

Collaborators and Investigators

• Sponsor: Mount Saint Vincent University
• Collaborators: Dairy Farmers of Canada

Study record dates

Study Major Dates

• Study Start (Actual): August 4, 2024
• Primary Completion (Estimated): August 31, 2025
• Study Completion (Estimated): December 31, 2025

Study Registration Dates

• First Submitted: August 1, 2024
• First Submitted That Met QC Criteria: August 20, 2024
• First Posted (Actual): August 23, 2024

Study Record Updates

• Last Update Posted (Estimated): August 29, 2025
• Last Update Submitted That Met QC Criteria: August 22, 2025
• Last Verified: August 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Food
• Other Study ID Numbers: 2023-147

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No