Daily Physical Activity After Meals -Long Term Effects on Blood Glucose

The postprandial blood glucose concentration is an important risk factor for development of cardiovascular diseases and diabetes. Previous studies have shown that one bout of moderate or light post-meal physical activity effectively blunts the postprandial increase in blood glucose after carbohydrate intake. Pre-meal exercise does not generate such effect. Thus, the effect of exercise on postprandial glycemia depend on the timing of exercise. Even very light physical activity decreases postprandial glycemia when performed in the postprandial period. The purpose of this study was to investigate whether such activity performed each day for 12 weeks would influence blood variables related to glycemic control.

METHODS 40 subjects being ethnic Norwegians or of South Asian origin were randomized into an intervention or a control group. They were previously diagnosed as hyperglycemic, or with high risk of type 2 diabetes according to Ramachandran's risc score.

Control subjects were told to maintain their usual physical activity patterns during the study period, while the intervention subjects were instructed to undertake a minimum of 30 minutes of daily post-meal physical activity in addition to their usual activity patterns.

Venous blood samples were taken before and after the 12 week intervention period. Plasma was analyzed for HbA1c and for fasting and 2hour (OGTT) values of glucose, insulin and c-peptide. The subjects kept a physical activity diary, answered questionnaires and used accelerometers to determine the level of physical activity.

Study Overview

• Status: Completed
• Conditions: Blood Glucose; Blood Glucose Related Variables
• Intervention / Treatment: Behavioral: Postprandial physical activity

• Study Type: Interventional
• Enrollment (Actual): 40
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Norway
  • Lillehammer, Norway, 2618
    • Lillehammer University College

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Hyperglycemia or high risk of type 2 diabetes due to Ramachandrans risk score

Exclusion Criteria:

• Use of hypoglycemic agents and conditions directly affecting blood glucose other than hyperglycemia per s.e. / diabetes type 2

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Control; maintain usual physical activity patterns
Experimental: Intervention; Addition of daily postprandial physical activity in addition to usual activity patterns	Behavioral: Postprandial physical activity; Adding a minimum of 30 minutes of physical activity starting maximum 30 minutes after the last meal daily

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Hba1c		Pre and post intervention which lasts an average of 12 weeks
Change in Fasted glucose		Pre and post intervention which lasts an average of 12 weeks
Change in 2hour glucose	Oral glucose tolerance test (OGTT)	Pre and post intervention which lasts an average of 12 weeks
Change in glucose during OGTT	glucose measured by finger sticks every 15. minute during the 2hour oral glucose tolerance test	Pre and post intervention which lasts an average of 12 weeks
Change in Physical fitness measured as heart rate during an exercise test	Heart rate measured at the end of 10 minutes ergometer cycle test an given intensity (low) to moderate intensity)	Measured pre and post intervention which lasts an average of 12 weeks
Change in Physical fitness measured as oxygen consumption during an exercise test	measured at the end of 10 minutes ergometer cycle test an given intensity (low) by indirect calorimetry	Measured pre and post intervention which lasts an average of 12 weeks
Change in Physical fitness measured as respiratory exchange rate during an exercise test	Measured at the end of 10 minutes ergometer cycle test an given intensity (low), by indirect calorimetry	Measured pre and post intervention which lasts an average of 12 weeks
Change in Physical fitness measured as perceived exertion during an exercise test	Borg RPE scale measured at the end of 10 minutes ergometer cycle test an given intensity (low)	Measured pre and post intervention which lasts an average of 12 weeks
Change in Physical fitness measured as lactic acid during an exercise test	measured at the end of 10 minutes ergometer cycle test an given intensity (low) from capillary blod from a finger stick	Measured pre and post intervention which lasts an average of 12 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Total cholesterol		Measured Pre and post intervention which lasts an average of 12 weeks
Change in LDL cholesterol		Measured Pre and post intervention which lasts an average of 12 weeks
Change in HDL cholesterol		Measured Pre and post intervention which lasts an average of 12 weeks
Change in triglycerides		Measured Pre and post intervention which lasts an average of 12 weeks
Change in body weight		Measured Pre and post intervention which lasts an average of 12 weeks
Change in waist circumference		Measured Pre and post intervention which lasts an average of 12 weeks
Change in Blood pressure		Measured Pre and post intervention which lasts an average of 12 weeks
Change in Quality of life	Quality of life measured by SF36	Measured Pre and post intervention which lasts an average of 12 weeks

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Level of physical activity	Measured by accelerometer	Measured for 4 days pre intervention and 4 days in the middle of intervention
Change in dietary habits	Measured by dietary registration with dietary diary and a kitchen scale	Measured for 4 days pre intervention and 4 days in the middle of intervention

Collaborators and Investigators

• Sponsor: Inland Norway University of Applied Sciences
• Collaborators: University of Oslo
• Investigators: Principal Investigator: Håvard Nygaard, MSc, Inland Norway University of Applied Sciences

Study record dates

Study Major Dates

• Study Start: September 1, 2010
• Primary Completion (Actual): June 1, 2014
• Study Completion (Actual): September 1, 2014

Study Registration Dates

• First Submitted: May 21, 2015
• First Submitted That Met QC Criteria: August 26, 2015
• First Posted (Estimate): August 31, 2015

Study Record Updates

• Last Update Posted (Estimate): August 31, 2015
• Last Update Submitted That Met QC Criteria: August 26, 2015
• Last Verified: August 1, 2015

More Information

Terms related to this study

• Other Study ID Numbers: PPPA99