Anomia Treatment Predictors

Predictors of Phonological-focused Anomia Treatment

The goal of this clinical trial is to identify predictors of response to phonological-focused anomia treatment in people with aphasia. The main question it aims to answer is who responds to which type of anomia treatment. Researchers will compare Phonomotor Treatment and Phonological Components Analysis to see which treatment is more beneficial, and for whom. Participants will engage in both treatments over several months.

Study Overview

• Status: Completed
• Conditions: Aphasia; Anomia (Word-Finding Impairment)
• Intervention / Treatment: Behavioral: Phonomotor Treatment (PMT); Behavioral: Phonological Components Analysis (PCA)

Detailed Description

Participants will complete screening and characterization testing to determine eligibility for the study. Each treatment will be administered twice a week, for 10-15 sessions. Pre-treatment and post-treatment testing will also occur for each treatment. There will be a period of no treatment in between the first and second treatment blocks.

• Study Type: Interventional
• Enrollment (Actual): 2
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • New York
    • Buffalo, New York, United States, 14214
      • UB Audiology and Speech-Language Pathology Clinic

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Chronic aphasia (6+ months)
• Anomia
• Sufficient auditory comprehension to follow task instructions
• Phonologic impairment

Exclusion Criteria:

• Progressive neurological illness or disease, including dementia
• Chronic medical illness that interferes with adherence to testing schedule
• Severe, uncorrected vision or hearing impairment that interferes with task completion
• Moderate-severe apraxia of speech or dysarthria that interferes with task completion

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: PMT; Phonomotor Treatment (PMT) will be administered. This treatment improves anomia by training the sound sequences of words. This is a multimodal treatment approach that includes listening, producing, visualizing, and describing sounds and sound sequences. The participant practices the sound sequence tasks with the clinician.	Behavioral: Phonomotor Treatment (PMT); Anomia treatment focuses on improving word-finding abilities. This intervention targets the phonology of words to improve word-finding.
Experimental: PCA; Phonological Components Analysis (PCA) will be administered. This treatment improves anomia by identifying phonological features of words. A picture is presented. The participant provides features of the picture name: the first sound of the word, the final sound of the word, the number of syllables of the word, another word that starts with the same sound, and another words that rhymes with the word. The participant attempts to produce the word independently and by repeating after the clinician.	Behavioral: Phonological Components Analysis (PCA); Anomia treatment focuses on improving word-finding abilities. This intervention targets the phonology of words to improve word-finding.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Naming of Trained Words	Picture naming of trained words	Pre-treatment and Immediately post-treatment

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Naming of Untrained Words	Picture naming of untrained words	Pre-treatment and Immediately post-treatment
Standardized Assessment of Phonology in Aphasia (SAPA)	The SAPA assesses phonological processing abilities, including oral reading, rhyme judgments, minimal pair judgments, lexical decision, blending, and parsing.	Pre-treatment and Immediately post-treatment
Philadelphia Naming Test	The short-form of the Philadelphia Naming Test is a picture naming test of items not seen during treatment.	Pre-treatment and Immediately post-treatment

Collaborators and Investigators

• Sponsor: State University of New York at Buffalo
• Investigators: Principal Investigator: Nichol Castro, PhD, SUNY at Buffalo

Study record dates

Study Major Dates

• Study Start (Actual): September 18, 2024
• Primary Completion (Actual): October 1, 2025
• Study Completion (Actual): October 1, 2025

Study Registration Dates

• First Submitted: September 27, 2024
• First Submitted That Met QC Criteria: September 27, 2024
• First Posted (Actual): October 1, 2024

Study Record Updates

• Last Update Posted (Actual): November 12, 2025
• Last Update Submitted That Met QC Criteria: November 7, 2025
• Last Verified: November 1, 2025

More Information

Terms related to this study

• Keywords: aphasia treatment; anomia treatment
• Additional Relevant MeSH Terms: Neurologic Manifestations; Nervous System Diseases; Neurobehavioral Manifestations; Communication Disorders; Language Disorders; Speech Disorders; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Aphasia; Anomia
• Other Study ID Numbers: STUDY00008623

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Sample size is low increasing risk of identification of individuals.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No