Modeling Treated Recovery From Aphasia

(C-STAR) Center for the Study of Aphasia Recovery Modeling Treated Recovery From Aphasia


Lead Sponsor: University of South Carolina

Collaborator: National Institute on Deafness and Other Communication Disorders (NIDCD)

Source University of South Carolina
Brief Summary

Stroke is the leading cause of adult disability in the United States, and aphasia is common following a stroke to the left hemisphere of the brain. Aphasia therapy can improve aphasia recover; however, very little is known about how different patients respond to different types of treatments. The purpose of this study is to understand how the following factors influence an individual's response to aphasia treatment: 1) biographical factors (e.g., age, education, gender), 2) post-stroke cognitive/linguistic abilities and learning potential, and 3) the location and extent of post-stroke brain damage. We are also interested in understanding the kinds of treatment materials that should be emphasized in speech/language treatment. Overall, the goal of the current research is to inform the clinical management of post-stroke aphasia by identifying factors that can predict how an individual will respond to different treatment methods.

Overall Status Recruiting
Start Date 2016-08-02
Completion Date 2021-06-01
Primary Completion Date 2021-06-01
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Philadelphia Naming Test 6 months
Enrollment 150

Intervention Type: Behavioral

Intervention Name: Semantically focused treatment

Description: Tasks are as follows: Semantic feature analysis (SFA): For each pictured stimulus the patient is prompted to name the picture, and then to produce related words that represent features similar to the target word. Semantic barrier task: The goal is for one participant (e.g., patient) to describe each card so that the other participant (e.g., clinician) can guess the picture on the card. Participants are only allowed to describe the semantic features of the target and the clinician models the kinds of cues that are allowed. Verb network strengthening treatment (VNeST): This treatment targets lexical retrieval of verbs and their thematic nouns. The objective of VNeST is for the patient to generate verb-noun associates with the purpose of strengthening the connections between the verb and its uses. These are tasks used in clinical aphasia rehabilitation.

Arm Group Label: Semantically focused treatment

Intervention Type: Behavioral

Intervention Name: Phonologically focused treatment

Description: Tasks are as follows: Phonological (sound) components analysis task: Participants are to name a given picture and then to identify the sound features of the target words (e.g., first sound, last sound, and rhyme). Phonological production task: This tasks asks participants to sort and identify the sounds that make up a word. Various stages include identifying first sounds, last sounds, etc. Participants also work on blending sounds together to form words. The phonological judgment task: A computerized presentation of verbs and nouns where participants are required to judge whether pairs of words include similar phonological features. These are tasks used in clinical aphasia rehabilitation.

Arm Group Label: Phonologically focused treatment



Inclusion Criteria: - Experienced a left hemisphere ischemic or hemorrhagic stroke At least 12 months post-stroke - Primarily English speaker for the past 20 years - Ability to provide informed written or verbal consent MRI-compatible (e.g., no metal implants, not claustrophobic) Exclusion Criteria: - History of a right hemisphere stroke (Bilateral stroke) - Clinically reported history of dementia, alcohol abuse, psychiatric disorder, traumatic brain injury, or extensive visual acuity or visual-spatial problems - Severely limited speech production and/or auditory comprehension that interferes with adequate participation in the therapy provided



Minimum Age:

21 Years

Maximum Age:

80 Years

Healthy Volunteers:


Overall Official
Last Name Role Affiliation
Julius Fridriksson, PhD, CCC-SLP Principal Investigator University of South Carolina
Overall Contact

Last Name: Leigh Ann Spell, PhD, CCC-SLP

Phone: 803-777-2693

Email: [email protected]

Facility: Status: Contact:
Medical University of South Carolina | Charleston, South Carolina, 29425, United States Recruiting Skyler Fotenot, MA, CCC-SLP 843-792-3678 [email protected]
University of South Carolina | Columbia, South Carolina, 29208, United States Recruiting Leigh Ann Spell, PhD, CCC-SLP 803-777-2693 [email protected] Julius Fridriksson, PhD Principal Investigator
Location Countries

United States

Verification Date


Responsible Party

Type: Principal Investigator

Investigator Affiliation: University of South Carolina

Investigator Full Name: Julius Fridriksson

Investigator Title: Endowed Professor

Has Expanded Access No
Condition Browse
Number Of Arms 2
Arm Group

Label: Semantically focused treatment

Type: Active Comparator

Description: This treatment will focus on improving word finding and comprehension of information.

Label: Phonologically focused treatment

Type: Active Comparator

Description: This treatment will focus on training speech sound production, targeting overall production abilities.

Study Design Info

Allocation: Randomized

Intervention Model: Crossover Assignment

Primary Purpose: Treatment

Masking: Single (Outcomes Assessor)

This information was retrieved directly from the website without any changes. If you have any requests to change, remove or update your study details, please contact [email protected]. As soon as a change is implemented on, this will be updated automatically on our website as well.

Clinical Research News