Socket Preservation After Surgical Extraction of Impacted Lower Third Molar

November 29, 2024 updated by: Wael Mohamed

Socket Preservation Using Autogenous Particulate Dentin in Combination With Liquid Platelet-rich Fibrin Versus Bone Allografts and Collagen Cones After Surgical Extraction of Impacted Lower Third Molar

The aim of this study will be to evaluate socket preservation using autogenous particulate dentin in combination with liquid platelet-rich fibrin versus bone allografts and collagen cone after surgical extraction of the horizontally impacted lower third molar

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The aim of this study will be to evaluate socket preservation using autogenous particulate dentin in combination with liquid platelet-rich fibrin (sticky tooth) versus bone allografts and collagen cone after surgical extraction of the horizontally impacted lower third molar

Study Type

Interventional

Enrollment (Actual)

45

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • Eldakahlia
      • Mansoura, Eldakahlia, Egypt, 35511
        • Mansoura University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  1. Fresh extracted socket of horizontally impacted mandibular third molar
  2. Co-operative patients willing to complete the follow-up periods.
  3. Patients age from 18-35 years.
  4. Good oral hygiene.

Exclusion Criteria:

  1. Any pathological condition at the site of surgery.
  2. Patients with systemic diseases that contra-indicate the surgical procedure such as uncontrolled diabetes mellitus, bleeding disorders, serious osseous disorders and mental disorders.
  3. Smokers .

  4. Pregnancy.

    -

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: socket preservation with dentine graft mixed with liquid platelet rich fibrin (sticky tooth)
socket preservation with dentine graft mixed with liquid platelet rich fibrin (sticky tooth) after surgical extraction of horizontally impacted lower wisdom
Biological: socket preservation using dentine graft mixed with i-PRF
surgical extraction of horizontally impacted third molar , placement of dentin graft mixed with i-PRF inside the socket , suturing
Active Comparator: socket preservation with bone allograft
socket preservation with bone allograft after surgical extraction of horizontally impacted lower wisdom
Biological: socket preservation using bone allograft
surgical extraction of horizontally impacted third molar , placement of bone allograft inside the socket , suturing
Active Comparator: socket preservation with collagen cone
socket preservation with collagen cone after surgical extraction of horizontally impacted lower wisdom
Biological: socket preservation using collagen cone
surgical extraction of horizontally impacted third molar , placement of collagen cone inside the socket , suturing

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
bone resorption distal to second molar
Time Frame: 3 months after extraction
by measuring bone level immediate and 3 months after extraction on CBCT
3 months after extraction

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
bone density
Time Frame: 3 months after extraction
using CBCT 3 month after extraction
3 months after extraction
edema
Time Frame: 4 days after extraction

by measuring distance between predetermined anatomical landmarks:

  • Mandibular angle and canthus of the eye.
  • Mandibular angle and corner of the mouth.
  • Mandibular angle and tragus.
  • Mandibular angle and pogonion.
4 days after extraction
pain after surgical extraction
Time Frame: 4 days after extraction
using numerical rating scale
4 days after extraction

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Wael Mohamed

Investigators

  • Principal Investigator: Wael M Ahmed, PHD, mansoura uniersity

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2022

Primary Completion (Actual)

December 15, 2023

Study Completion (Actual)

April 1, 2024

Study Registration Dates

First Submitted

November 29, 2024

First Submitted That Met QC Criteria

November 29, 2024

First Posted (Estimated)

December 4, 2024

Study Record Updates

Last Update Posted (Estimated)

December 4, 2024

Last Update Submitted That Met QC Criteria

November 29, 2024

Last Verified

November 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • A08061222

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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