Comparison of LASER Therapy and Desensitizing Agents in Dentinal Hypersensitivity

Comparison of Mean Pain Score Using LASER Therapy and Desensitizing Agents in Patients With Dentinal Hypersensitivity: A Randomized Controlled Trial

This study evaluates the effectiveness of laser therapy versus desensitizing agents in reducing pain among participants with dentinal hypersensitivity conducted in Saidu College of Dentistry. Pain will be measured at baseline, immediately post-treatment, one week, and three months using the Visual Analog Scale (VAS)

Study Overview

• Status: Not yet recruiting
• Conditions: Dentinal Hypersensitivity
• Intervention / Treatment: Drug: Glutaraldehyde-Based Desensetizing Agent; Device: Low Level Laser Therapy

Detailed Description

This study examines dentinal hypersensitivity treatment modalities, including laser therapy and desensitizing agents. The study is conducted in compliance with regional ethical guidelines

• Study Type: Interventional
• Enrollment (Estimated): 172
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Brekhna Yousafzai; Phone Number: +923417262127; Email: kemiagul3456@gmail.com
• Study Contact Backup: Name: Kemia Gul; Phone Number: +923352803890; Email: brekhna.apple123@gmail.com

Study Locations

• Pakistan
  • KPK
    • Swat, KPK, Pakistan
      • Saidu College of Dentistry
      • Principal Investigator: BREKHNA YOUSAFZAI
      • Sub-Investigator: KEMIA GUL
      • Sub-Investigator: FAYYAZ ALAM
      • Contact: Saidu College of Dentistry Saidu Sharif Swat; Phone Number: 009469240142; Email: info.scdswat@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Participants aged 18-50 years with a preoperative VAS score of ≥2 for dentinal hypersensitivity.
• Participants with sensitivity due to gingival recession, cervical abrasion, or enamel erosion.
• Participants with good systemic health.
• Minimum of two hypersensitive teeth present in two different quadrants.

Exclusion Criteria:

• Teeth with caries, defective restorations, or cervical defects > 2 mm (may affect sensitivity measurements).
• Periodontal surgery or deep periodontal pockets (> 6 mm) within the past three months (potential influence on periodontal health and sensitivity).
• Participants using desensitizing toothpaste within the past three months (could interfere with study outcomes).
• Presence of gross oral pathology or systemic diseases (e.g., eating disorders, chronic diseases, uncontrolled metabolic conditions) (may alter oral health status).
• Pregnant or lactating women (hormonal changes can influence oral health).

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Arm 1 (Desensitizing Agent); A glutaraldehyde-based desensitizing agent applied to affected teeth for 30 seconds, air-dried, with post-application instructions	Drug: Glutaraldehyde-Based Desensetizing Agent; A glutaraldehyde-based desensitizing agent applied to the cervical area of affected teeth using a micro-brush, left undisturbed for 30 seconds, and air-dried. Both interventions aim to reduce pain associated with dentinal hypersensitivity by either occluding dentinal tubules or reducing nerve excitability
Experimental: Arm 2 (Laser Therapy); Diode laser set to 100 mW in continuous wave mode, applied to specific areas of affected teeth for three minutes	Device: Low Level Laser Therapy; Low-level laser therapy (LLLT) using a diode laser set to a low power level (e.g., 100 mW, continuous wave mode). Each affected tooth will be treated for three minutes, targeting apical, cervical, and middle points

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in pain intensity: Visual Analog Scale	After intervention there is a possibility of change in pain intensity in Dentinal Hypersensitivity	Immediately post-treatment, one week, and three months

Collaborators and Investigators

• Sponsor: Kemia Gul
• Investigators: Principal Investigator: BREKHNA YOUSAFZAI, Saidu College of Dentistry

Study record dates

Study Major Dates

• Study Start (Estimated): June 30, 2025
• Primary Completion (Estimated): December 31, 2025
• Study Completion (Estimated): June 30, 2026

Study Registration Dates

• First Submitted: December 28, 2024
• First Submitted That Met QC Criteria: January 3, 2025
• First Posted (Actual): January 6, 2025

Study Record Updates

• Last Update Posted (Actual): May 11, 2025
• Last Update Submitted That Met QC Criteria: May 7, 2025
• Last Verified: May 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Immune System Diseases; Hypersensitivity; Anti-Infective Agents; Disinfectants; Glutaral
• Other Study ID Numbers: 208-ERB/024

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: IPD will not be shared with other researchers due to confidentiality concerns, ethical considerations, and the absence of any formal plan for data sharing at this time

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: Yes
• product manufactured in and exported from the U.S.: Yes