Risk Factors of Failure of Conservative Treatment in Acute Non Complicated Appendicitis (appendicitis)

February 13, 2025 updated by: Ahmed Mohammed Hussein Sayed
From this study, it can be concluded that patients who meet the following criteria are more likely to fail expectant management and thus should not be considered for the NOM of uncomplicated acute appendicitis. These include the duration of symptoms before presenting to a surgical emergency , the presence of fever within 24 hours of presenting to a surgical emergency, TLC cells/dL, CRP mg/L, appendix diameter mm, modified Alvarado score , and adult appendicitis score .

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Expectant management with intravenous antibiotic therapy alone has emerged as an effective alternative to appendectomy for the treatment of uncomplicated acute appendicitis . It is important to identify patients at the onset of the disease who are likely to have successful outcomes for conservative management.

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • Egypt
      • Assuit, Egypt, 71515
        • Assiut University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Male or female patients é diagnosis of acute appendicitis Patients with ages: from 16 to 60 years old

Description

Inclusion Criteria:

  • Male or female patients é diagnosis of acute appendicitis .
  • Patients with ages: from 16 to 60 years old.

Exclusion Criteria:

  • complicated AA (appendicolith, perforation, peri appendicular abscess or suspicion of a tumor).
  • inflammatory bowel disease.
  • inability to co-operate and give informed consent.
  • diffuse peritonitis.
  • antibiotic documented allergy & allergy to contrast media .
  • Patients with serious comorbid conditions DM & renal insufficiency, serum creatinine > 150 μmol/l .
  • Pregnant & lactating patient.
  • Patients with bleeding diathesis and those on anticoagulants.
  • Patients with advanced malignancies & patient on immunosuppressive drugs .
  • Patients with previous appendectomy.
  • Extreme of age.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
(1) Male or female patients é diagnosis of acute appendicitis.
Patients who presented with complaints of right lower quadrant pain with symptoms and signs strongly suggestive of uncomplicated acute appendicitis that was confirmed on ultrasonography, were included. The modified Alvarado score and adult appendicitis score were calculated.
Drug: ceftriaxone
ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly
Drug: ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly
Conservative management

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Risk factors of failure of conservative treatment in acute non complicated appendicitis
Time Frame: One year
modified Alvarado score and adult appendicitis score
One year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ahmed Mohammed Hussein Sayed

Collaborators

Assiut University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

June 22, 2025

Primary Completion (Estimated)

December 1, 2025

Study Completion (Estimated)

December 2, 2025

Study Registration Dates

First Submitted

December 4, 2024

First Submitted That Met QC Criteria

February 13, 2025

First Posted (Actual)

March 25, 2025

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

February 13, 2025

Last Verified

December 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • acute appendicitis

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Conservative Management

Clinical Trials on ceftriaxone

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Tanzania

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe