Efficacy Evaluation of Blood Peach Extract and Rose Apple Extract on Skin

Evaluate the effects of blood peach extract drink and rose apple extract drink on enhancing hemoglobin and iron levels, and improving skin health.

Study Overview

• Status: Completed
• Conditions: Dermatology
• Intervention / Treatment: Dietary supplement: Placebo Drink; Dietary supplement: Blood Peach Extract Drink; Dietary supplement: Rose Apple Extract Drink

• Study Type: Interventional
• Enrollment (Actual): 75
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Taichung City, Taiwan, 406040
    • China Medical University of Department of Cosmeceutics

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy adult females aged 20 to 65;
• Preferably those with pale complexion or signs of iron deficiency anemia.

Exclusion Criteria:

• Currently undergoing or having undergone any medical beauty treatments within the past month (including skincare, laser treatments, chemical peel, injections, or cosmetic surgery);
• Outdoor workers (exposed to sunlight for more than 5 hours daily);
• Pregnant, breastfeeding, or planning to become pregnant during the trial (self-reported);
• Individuals with heart, liver, kidney, endocrine, or other significant organic diseases (self-reported);
• Individuals who have undergone major surgery (according to medical history);
• Long-term medication users;
• Individuals with mental health disorders;
• Those who are already regularly taking iron supplements;
• Faculty or staff members who are currently enrolled in the principal investigator's courses.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo	Dietary supplement: Placebo Drink; Take one bottle of the product every morning on an empty stomach
Experimental: Blood Peach Extract	Dietary supplement: Blood Peach Extract Drink; Take one bottle of the product every morning on an empty stomach
Experimental: Rose Apple Extract	Dietary supplement: Rose Apple Extract Drink; Take one bottle of the product every morning on an empty stomach

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
the volume of skin wrinkles	IRV full-face skin analyzer was utilized to measure skin wrinkles. Units: arbitrary units	Volume change from Baseline skin wrinkles at 8 weeks
the roughness of skin texture	IRV full-face skin analyzer was utilized to measure skin texture. Units: arbitrary units	Rating skin roughness from Baseline skin texture at 8 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
the change of skin elasticity	Cutometer® was utilized to measure skin elasticity. Units: arbitrary units	Change from Baseline skin elasticity at 8 weeks
the change of skin collagen density	Dermalab® Combo was utilized to measure skin collagen density. Units: arbitrary units	Change from Baseline skin collagen density at 8 weeks
the change of skin pores	IRV full-face skin analyzer was utilized to measure skin pores. Units: arbitrary units	Change from Baseline skin pores at 8 weeks
the change of skin tone	IRV full-face skin analyzer was utilized to measure skin tone. Units: arbitrary units	Change from Baseline skin tone at 8 weeks
the change of skin hydration	Corneometer® was utilized to measure skin hydration. Units: arbitrary units	Change from Baseline skin hydration at 8 weeks
the change of skin melanin/erythema index	Mexameter® was utilized to measure skin melanin/erythema index. Units: arbitrary units	Change from Baseline skin melanin/erythema index at 8 weeks
the change of skin redness	Colorimeter was utilized to measure skin redness. Units: arbitrary units	Change from Baseline skin redness at 8 weeks
the change of lip redness	Antera 3D® was utilized to measure lip redness. Units: arbitrary units	Change from Baseline lip redness at 8 weeks
the change of Red Blood Cells (RBC) Count of blood	venous blood was sampled to measure RBC count	Change from Baseline RBC count at 8 weeks
the change of hemoglobin level of blood	venous blood was sampled to measure hemoglobin level	Change from Baseline hemoglobin level at 8 weeks
the change of mean corpuscular volume (M.C.V) level of blood	venous blood was sampled to measure M.C.V level	Change from Baseline M.C.V level at 8 weeks
the change of mean corpuscular hemoglobin concentration (M.C.H.C) level of blood	venous blood was sampled to measure M.C.H.C level	Change from Baseline M.C.H.C level at 8 weeks
the change of ferrous level of blood	venous blood was sampled to measure ferrous level	Change from Baseline ferrous level at 8 weeks
the change of ferritin level of blood	venous blood was sampled to measure ferritin level	Change from Baseline ferritin level at 8 weeks
the change of Total Iron Binding Capacity (TIBC) level of blood	venous blood was sampled to measure TIBC level	Change from Baseline TIBC level at 8 weeks
the change of unsaturated iron-binding capacity (UIBC) level of blood	venous blood was sampled to measure UIBC level	Change from Baseline UIBC level at 8 weeks

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
the change of liver function biomarkers (AST, ALT) of blood	venous blood was sampled to measure liver function biomarkers	change from Baseline liver function biomarkers at 8 weeks
the change of renal function biomarkers (creatinine, BUN) of blood	venous blood was sampled to measure renal function biomarkers	change from Baseline renal function biomarkers at 8 weeks
the change of fasting glucose level of blood	venous blood was sampled to measure fasting glucose level	change from Baseline fasting glucose level at 8 weeks
the change of Advanced glycation end products (AGEs) level of blood	venous blood was sampled to measure AGEs level	change from Baseline AGEs level at 8 weeks
The change of self-assessment skin and metabolic circulation condition	A self-assessment questionnaire was collected to evaluate skin and metabolic circulation condition. As for the evalutation of skin condition, the higher score the better; As for evaluation of metabolic circulation condition, the higher score the worse.	Change from Baseline skin and metabolic circulation condition at 8 weeks

Collaborators and Investigators

• Sponsor: TCI Co., Ltd.
• Investigators: Principal Investigator: Hsiu-Mei Chiang, China Medical University of Department of Cosmeceutics

Study record dates

Study Major Dates

• Study Start (Actual): April 7, 2025
• Primary Completion (Actual): June 30, 2025
• Study Completion (Actual): July 15, 2025

Study Registration Dates

• First Submitted: February 25, 2025
• First Submitted That Met QC Criteria: February 25, 2025
• First Posted (Actual): March 3, 2025

Study Record Updates

• Last Update Posted (Actual): July 30, 2025
• Last Update Submitted That Met QC Criteria: July 28, 2025
• Last Verified: July 1, 2025

More Information

Terms related to this study

• Keywords: skin analysis; skin care products
• Other Study ID Numbers: CMUH114-REC3-005

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No