Investigation of the Effectiveness of Lung Ultrasonography in Intraoperative Fluid Management

Investigation of the Effectiveness of Lung Ultrasonography in the Management of Intraoperative Fluid Therapy, Prospective Observational Study

Adequate and balanced fluid resuscitation is one of the cornerstones of intraoperative patient management. Over-resuscitation leading to positive fluid balance is associated with increased postoperative mortality and morbidity.

Invasive and non-invasive technologies can be used for the adequacy of intraoperative fluid therapy.

Lung ultrasonography (LUS) is a safe and accurate bedside imaging method. LUS, which is frequently used in the diagnosis of postoperative hypoxemia, has also begun to be preferred for fluid management in intensive care units.

Study Overview

• Status: Not yet recruiting
• Conditions: Intraoperative Fluid Management
• Intervention / Treatment: Device: Lung ultrasound

Detailed Description

In this study, we aimed to investigate the effectiveness of intraoperative LUS data in the control of fluid therapy.

• Study Type: Observational
• Enrollment (Estimated): 50

Contacts and Locations

• Study Contact: Name: Korgün Ökmen, PhD.; Phone Number: 05057081021; Email: korgunokmen@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Patients who will undergo open surgery in ASA I-III risk classes.

Description

Inclusion Criteria:

• Patients with surgery with laparotomy

Exclusion Criteria:

• Chronic obstructive pulmonary disease
• Passed lung operation
• Uncontrolled hypertension
• Acute or chronic kidney failure

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
LUS	Lung ultrasound score (LUS) Lung ultrasonography; Lung ultrasound score will be created by performing ultrasonography in 4 quadrants according to the previously defined protocol. 0 points indicated the presence of only A lines, less than 2 B lines; point indicated 1-2 B lines; points indicated the presence of more than 3 well-spaced B lines;; points indicated the presence of combined B lines	peroperative

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
PVI	Pulse variable index (PVI) will be measured by finger pulse oximetry with the MASİMO device.	peroperative
CVP	Central venous pressure(CVP) Pressure values measured by a central venous catheter applied by jugular or subclavian route	peroperative
postoperative pulmonary complication	hypoxia (partial oxygen pressure below 95 on pulse oximetry and 10% decrease from the initial value) atelectasis	postoperative 6th hour
biochemical data 1	glomerular filtration rate (GFR) values normal results range from 90 to 120 mL/min/1.73 m2.	postoperative 6th hour
biochemical data 2	Blood urea nitrogen value mg/dl	postoperative 6th hour
biochemical data 3	Blood creatinine value mmol/dl	postoperative 6th hour
Mechanical ventilation data 1	End-Tidal Carbon Dioxide Pressure mm/hg The partial pressure of CO2 detected at the end of exhalation is between 35 and 45 mm Hg or 4.0 to 5.7 kPa.	peroperative
Mechanical ventilation data 2	Peak inspiratory pressure Values Peak inspiratory pressure is the highest pressure applied to the lungs during inhalation and should be kept below 35 cmH2O.It is automatically measured by respirators.	peroperative
Mechanical ventilation data 3	Tidal Volume value Tidal volume is the volume of gas moving into and out of the lungs with each breath. Normal tidal volume is 6 to 8 mL/kg, regardless of age. It is automatically measured by respirators.	peroperative

Collaborators and Investigators

• Sponsor: Korgün Ökmen

Study record dates

Study Major Dates

• Study Start (Estimated): May 20, 2025
• Primary Completion (Estimated): May 20, 2026
• Study Completion (Estimated): May 30, 2026

Study Registration Dates

• First Submitted: April 25, 2025
• First Submitted That Met QC Criteria: May 2, 2025
• First Posted (Actual): May 11, 2025

Study Record Updates

• Last Update Posted (Actual): May 15, 2025
• Last Update Submitted That Met QC Criteria: May 13, 2025
• Last Verified: May 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: BursaYIEAH-2021-6-10

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No