Association Between Ambient Temperature and Myocardial Injury After Noncardiac Surgery in Adults

Association Between Ambient Temperature and Myocardial Injury After Noncardiac Surgery in Adults: a Retrospective Single-center Cohort Study

This single-center retrospective cohort study enrolled patients aged ≥18 years who underwent noncardiac surgery between January 2014 and December 2023. The exposure variable was the 7-day average preoperative ambient temperature in Beijing. Univariate and multivariate logistic regression models were used to evaluate the association between temperature and MINS. Inverse probability of treatment weighting (IPTW) analysis was performed to enhance the robustness of the findings. Subgroup analyses were performed across predefined clinical strata.

Study Overview

• Status: Completed
• Conditions: MINS
• Intervention / Treatment: Other: MINS

• Study Type: Observational
• Enrollment (Actual): 143095

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

This retrospective single-center cohort study included 143,095 adult (≥18 years) patients who underwent noncardiac surgery under general anesthesia between January 2014 and December 2023. The exclusion criteria were as follows: (1) American Society of Anesthesiologists (ASA) classification V; (2) outpatient, hysteroscopic, or body surface surgeries; (3) surgery duration ≤30 min; (4) absence of postoperative high-sensitivity troponin T (hs-TnT) testing within 30 days; and (5) incomplete clinical data (≥20% missing data).

Description

Inclusion Criteria:

• ≥18 years
• underwent noncardiac surgery under general anesthesia

Exclusion Criteria:

• American Society of Anesthesiologists (ASA) classification V;
• outpatient, hysteroscopic, or body surface surgeries
• surgery duration ≤30 min
• absence of postoperative high-sensitivity troponin T (hs-TnT) testing within 30 days
• incomplete clinical data (≥20% missing data)

Study Plan

How is the study designed?

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
moderate heat (22.8℃-29.2℃)	Other: MINS; MINS
extreme heat (≥29.2℃)	Other: MINS; MINS
extreme cold (≤-3.5℃)	Other: MINS; MINS
moderate cold (-3.5℃-22.8℃)	Other: MINS; MINS

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
incidence of MINS	POSTOPERATIVE 30 DAYS

Collaborators and Investigators

• Sponsor: Hao Li

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2013
• Primary Completion (Actual): December 31, 2023
• Study Completion (Actual): December 31, 2023

Study Registration Dates

• First Submitted: June 30, 2025
• First Submitted That Met QC Criteria: July 14, 2025
• First Posted (Actual): July 23, 2025

Study Record Updates

• Last Update Posted (Actual): July 23, 2025
• Last Update Submitted That Met QC Criteria: July 14, 2025
• Last Verified: July 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: 20256030

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No