Effectiveness of Isokinetic Exercises in Proprioception for Post-stroke Patients

February 22, 2026 updated by: Ayse Naz Kalem, Ankara Etlik City Hospital

Evaluation of the Effect of Knee Isokinetic Strengthening Exercises on Proprioception and Balance in Stroke Patients

Somatosensory dysfunction including the sense of movement and position, i.e. proprioception, is observed in approximately 65% of patients after stroke. Loss of muscle strength, especially in the lower extremities, and impaired proprioception lead to significant loss of function in stroke patients. In addition, recent studies have emphasised that sensory information obtained by target-oriented exercises plays an important role in neuroplasticity and proprioception is an important element. The aim of this study was to evaluate the effect of knee isokinetic muscle strengthening exercises on proprioception and balance in stroke patients.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

34

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Ayse Naz Kalem Ozgen, Specialist
  • Phone Number: +90 0312 797 00 00
  • Email: kalemnaz@gmail.com

Study Locations

  • Turkey (Türkiye)
    • Yenimahalle
      • Ankara, Yenimahalle, Turkey (Türkiye)
        • Recruiting
        • Ankara Etlik City Hospital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • At least 3 months and no more than 1 year must have passed since the date of the incident
  • Be between 35 and 75 years of age
  • Manual muscle testing of the affected lower extremity shows at least 3 in ankle dorsiflexion and knee extension
  • No limitation in passive joint range of motion in the lower extremity
  • Mini mental test score > 23

Exclusion Criteria:

  • Presence of spasticity according to the modified Ashworth scale > 1+
  • Presence of neurological disease other than stroke
  • Presence of other medical conditions that may cause sensorimotor dysfunction in the lower extremities (e.g., diabetic polyneuropathy)
  • Presence of orthopaedic problems affecting lower extremity function
  • Previous history of stroke or ischaemic attack
  • Poor general health status (e.g. severe heart failure, COPD)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Conventional Rehabilitation
Patients will receive 15 sessions of conventional rehabilitation
Other: Conventional rehabilitation program
Ambulation and balance exercises
Experimental: isokinetic Exercise
Patients will receive 15 sessions of conventional rehabilitation and 10 sessions of knee isokinetic strengthening exercise therapy for the paretic lower extremity for 3 weeks. Isokinetic strengthening exercises will be performed using Cybex 770, Humac Norm dynamometer (CSMI, Stoughton, MA, USA).
Other: Conventional rehabilitation program
Ambulation and balance exercises
Device: Isokinetic Exercises
Exercises will be performed at three different angular speeds (90 ̊/sec, 5 repetitions, 5 sets; 120 ̊/sec, 8 repetitions, 5 sets; 150 ̊/sec, 10 repetitions, 5 sets).

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Proprioception assessment with isokinetic test device
Time Frame: before treatment and at the 3rd week of treatment
before treatment and at the 3rd week of treatment

Secondary Outcome Measures

Outcome Measure
Time Frame
Berg scale
Time Frame: Before treatment and at 3rd week of treatment
Before treatment and at 3rd week of treatment
Time up and Go Test
Time Frame: Before treatment and at the 3rd week of treatment
Before treatment and at the 3rd week of treatment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ankara Etlik City Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 1, 2025

Primary Completion (Estimated)

March 31, 2026

Study Completion (Estimated)

March 31, 2026

Study Registration Dates

First Submitted

July 23, 2025

First Submitted That Met QC Criteria

August 3, 2025

First Posted (Actual)

August 6, 2025

Study Record Updates

Last Update Posted (Actual)

February 24, 2026

Last Update Submitted That Met QC Criteria

February 22, 2026

Last Verified

July 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • AEŞH-EK-2025-012

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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