Call for Life: Exploring mHealth Solutions for Enhancing Childhood Vaccinations Among Displaced Children in Conflict-affected Settings of Nigeria (Call 4 Life)

This study evaluates the feasibility and preliminary impact of Call for Life, an mHealth platform aimed at increasing childhood vaccination coverage among internally displaced persons in Borno State, Nigeria. The platform uses an interactive voice response (IVR) system to deliver automated vaccination reminders, follow up on reported side effects, and provide health messages in English and local languages. A mixed-methods design is used to assess feasibility, interaction rates, and early effects on vaccine uptake. Findings will inform policymakers and humanitarian actors on the potential of mobile technology to strengthen immunization delivery in conflict-affected, resource-limited settings.

Study Overview

• Status: Enrolling by invitation
• Conditions: Access to Immunization
• Intervention / Treatment: Other: Telephone calls

• Study Type: Interventional
• Enrollment (Estimated): 366
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Nigeria
  • Borno State
    • Jere, Borno State, Nigeria
      • El Miskin

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• • Caregivers (male/female) of children from 0-23 months of age or pregnant women in third trimester

  • Caregivers above the age of 18 years of age
  • Caregivers who consent to participate in the study.
  • Resident in the IDP camp for at least one year

Exclusion Criteria:

• • Pregnant women in third trimester in first pregnancy (primigravida)

  • Caregivers that are temporary residents of the IDP camps (IDPs on transit or visitors)
  • Caregivers without the mental capacity to comprehend the questions asked.
  • Inability to use or interact with a mobile phone ( e.g. those with hearing defects or poor vision)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Health Services Research
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Call4life; Care givers will be reminded using telephone calls to go vaccine their children	Other: Telephone calls; Regular telephone reminders and health information will be sent to help mothers or caregivers of children 0-23 months to remind them to go vaccine their children; Other Names: Call4life

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of zero-dose children aged 0-23 months vaccinated and registered in an immunization registry at the health facility	Number of zero-dose children aged 0-23 months vaccinated and registered in an immunization registry at the health facility. The immunization registry which will be used by the health facility to follow up with parents for the vaccination schedules of the children	6 months
Number of care givers to children aged 0-23 months who receive reminder calls from the call for life platform and take their children to the health facility for immunization	Number of care givers to children aged 0-23 months who receive reminder calls from the call for life platform and take their children to the health facility for immunization and registration into an immunization registry	6 months

Collaborators and Investigators

• Sponsor: University of Cambridge
• Collaborators: University of Maiduguri; Infectious Disease Institute at Makerere University

Study record dates

Study Major Dates

• Study Start (Actual): June 24, 2025
• Primary Completion (Estimated): November 24, 2025
• Study Completion (Estimated): December 30, 2025

Study Registration Dates

• First Submitted: August 15, 2025
• First Submitted That Met QC Criteria: August 26, 2025
• First Posted (Estimated): September 4, 2025

Study Record Updates

• Last Update Posted (Estimated): September 4, 2025
• Last Update Submitted That Met QC Criteria: August 26, 2025
• Last Verified: August 1, 2025

More Information

Terms related to this study

• Keywords: mhealth; Immunization
• Other Study ID Numbers: Call-4-Life; Not application (Other Identifier: Cambridge Africa)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: IDP will be shared with researchers involved in the study.
• IPD Sharing Time Frame: January 2025 to December 2025
• IPD Sharing Access Criteria: Only researchers involved in the study will have access to IPD
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL; SAP

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No