Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder

February 10, 2026 updated by: University of Minnesota
The overall goal of this study is to investigate the added benefit of a neuromodulation intervention in individuals under buprenorphine maintenance treatment for OUD (bOUD).

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

160

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • United States
    • Minnesota
      • Minneapolis, Minnesota, United States, 55455
        • Recruiting
        • University of Minnesota
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • ability to provide consent and comply with study procedures
  • Diagnostic and Statistical Manual of Mental Disorders criteria for OUD
  • undergoing buprenorphine maintenance treatment. Participants may have current comorbid drug use, but primary diagnosis must be OUD
  • Intention to remain in the addiction treatment program until intervention completion.

Exclusion Criteria:

  • Any medical condition with neurological sequelae
  • head injury resulting in skull fracture or loss of consciousness of >30 minutes
  • any tDCS or MRI contraindication (tDCS: history of seizures, metallic cranial plates/screws or implanted device, history of eczema on scalp. MRI: unapproved metallic implants, pacemakers or any other implanted electrical device, shrapnel, metallic braces, non-removable body piercings, pregnancy, breathing or movement disorder, or claustrophobia)
  • any psychotic disorder (participants with other treated and stable psychiatric disorders will be included)
  • presence of a condition that would render study measures impossible to administer or interpret
  • age younger than 18
  • primary current substance use disorder on a substance other than opioids except for caffeine or nicotine
  • court mandated treatment
  • pregnancy
  • disrespectful behavior towards the investigators and staff.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: tDCS
All intervention sessions will use the Soterix Mini-CT Remote tDCS device
Device: Transcranial Direct Current Stimulation (tDCS)
We will deliver 2-mA tDCS current intensity during a 30 minute stimulation period (including a 30-second ramp-up and 30-second ramp-down period) to the dorsolateral prefrontal cortex. Electrodes will be fixed on marked locations based on the 10-20 EEG system. Anodal stimulating electrode will be over the left DLPFC (F3) and cathodal electrode over the right DLPFC (F4).
Placebo Comparator: Sham Electrodes
Device: Sham Stimulation
electrodes will have the same montage as active tDCS (F3/F4), but current will be ramped down after the initial 30 seconds ramp-up period. Thus, participants will feel the initial sensation associated with tDCS but will receive no active current for the rest of the stimulation period.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
tDCS effect on circuit-based target engagement of a prefrontal-incentive salience network
Time Frame: immediately after the intervention
Compare change in correlation value (which represents the functional connectivity between pre-frontal cortex and prefrontal-incentive salience network) via paired t-test, from pre- to post-intervention
immediately after the intervention
tDCS effect on executive functioning
Time Frame: immediately after the intervention
Compare change in mean cognitive performance via paired t-test from pre-intervention cognitive assessment to post-intervention cognitive assessment (post-intervention mean cognitive score minus pre-intervention mean cognitive score) between active tDCS and sham groups
immediately after the intervention

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Minnesota

Investigators

  • Principal Investigator: Jazmin Camchong, PhD, University of Minnesota

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 4, 2026

Primary Completion (Estimated)

August 1, 2026

Study Completion (Estimated)

August 1, 2026

Study Registration Dates

First Submitted

August 11, 2025

First Submitted That Met QC Criteria

September 2, 2025

First Posted (Actual)

September 8, 2025

Study Record Updates

Last Update Posted (Actual)

February 12, 2026

Last Update Submitted That Met QC Criteria

February 10, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PSYCH-2025-34164

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

Yes

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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