DEXDES Trial: Dexmedetomidine-Desflurane Combination in Laparoscopic Colectomy

December 28, 2025 updated by: Tam Anh Research Institute

Efficacy and Safety of Dexmedetomidine Combined With Desflurane in Laparoscopic Colectomy: A Randomized Double-Blind Controlled Clinical Trial (DEXDES Trial)

This randomized double-blind controlled clinical trial aims to evaluate the efficacy and safety of combining Dexmedetomidine with Desflurane in patients undergoing elective laparoscopic colectomy. The study will assess whether the combination can reduce Desflurane consumption, improve intraoperative hemodynamic stability, and enhance postoperative recovery compared to Desflurane alone.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Dexmedetomidine, a selective alpha-2 adrenergic agonist, has sedative and analgesic properties without significant respiratory depression. Desflurane, a volatile anesthetic with low blood-gas solubility, allows rapid induction and emergence. Combining these two agents may provide anesthetic-sparing effects and promote faster postoperative recovery under ERAS protocols. This study will enroll 40 adult patients undergoing elective laparoscopic colectomy at Tam Anh General Hospital, Vietnam. Participants will be randomized into two groups: Dexmedetomidine + Desflurane versus Desflurane alone. The primary outcome is average Desflurane consumption per hour, with secondary outcomes including hemodynamic parameters, Fentanyl use, emergence quality, and incidence of postoperative nausea and vomiting.

Study Type

Interventional

Enrollment (Estimated)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Vietnam
    • Ho Chi Minh
      • Ho Chi Minh City, Ho Chi Minh, Vietnam, 700000
        • Recruiting
        • Tam Anh TP. Ho Chi Minh General Hospital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Age 18-65 years
  • ASA Physical Status I-II
  • Elective laparoscopic colectomy
  • Written informed consent provided

Exclusion Criteria:

  • Severe cardiac, hepatic, or renal disease
  • COPD or bronchial asthma
  • Chronic opioid or psychotropic medication use
  • Atrioventricular block (grade II-III), sick sinus syndrome
  • Significant intraoperative bleeding or hemodynamic instability

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Intervention Group

Arm 1 - Dexmedetomidine + Desflurane (Intervention Group):

Dexmedetomidine bolus 1 µg/kg IV over 15 minutes before induction, followed by continuous infusion 0.5 µg/kg/h during surgery.

Desflurane administered at 1 MAC with EtControl mode.
Drug: Dexmedetomidine + Desflurane

Dexmedetomidine bolus 1 µg/kg IV over 15 minutes before induction, followed by continuous infusion 0.5 µg/kg/h during surgery.

Desflurane administered at 1 MAC with EtControl mode.
Placebo Comparator: Control Group

Arm 2 - Desflurane + Normal Saline (Control Group):

Normal saline infusion with identical timing and volume as the intervention group.

Desflurane administered at 1 MAC with EtControl mode
Drug: Desflurane + Normal Saline

Normal saline infusion with identical timing and volume as the intervention group.

Desflurane administered at 1 MAC with EtControl mode.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Average Desflurane consumption per hour (mL/h) during surgery.
Time Frame: During surgery
Average Desflurane consumption per hour (mL/h) during surgery.
During surgery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Tam Anh Research Institute

Collaborators

Tam Anh TP. Ho Chi Minh General Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2025

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

January 30, 2027

Study Registration Dates

First Submitted

November 16, 2025

First Submitted That Met QC Criteria

November 16, 2025

First Posted (Estimated)

November 20, 2025

Study Record Updates

Last Update Posted (Actual)

December 30, 2025

Last Update Submitted That Met QC Criteria

December 28, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • TA2.25.11

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Individual patient data (IPD) will remain confidential. Aggregated, de-identified data may be shared upon reasonable request after study completion for academic purposes.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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