Study on the Clinical Outcomes of ABO-Incompatible Living Donor Liver Transplantation

May 18, 2026 updated by: Zhi-Jun Zhu
Evaluate the postoperative survival rate and incidence of rejection in patients undergoing ABO-incompatible living donor liver transplantation; analyze the occurrence of secondary endpoint events such as postoperative vascular complications and biliary complications; and explore relevant risk factors affecting prognosis.

Study Overview

Status

Enrolling by invitation

Conditions

Detailed Description

Prospective and retrospective

Study Type

Observational

Enrollment (Estimated)

100

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

All eligible patients who underwent ABO-incompatible living donor liver transplantation between January 1, 2014 and December 31, 2028 and met the inclusion and exclusion criteria.

Description

Inclusion Criteria:

  1. Underwent ABO-incompatible living donor liver transplantation
  2. Complete and intact clinical and follow-up data

Exclusion Criteria:

  1. Non-primary liver transplantation
  2. Combined other organ transplantation
  3. Incomplete clinical data or loss to follow-up

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
ABO-Incompatible Living Donor Liver Transplantation Patients
Evaluate the postoperative survival rate and incidence of rejection in patients undergoing ABO-incompatible living donor liver transplantation; analyze the occurrence of secondary endpoint events such as postoperative vascular complications and biliary complications; and explore relevant risk factors affecting prognosis.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Postoperative survival rate
Time Frame: Minimum follow-up period of 1 year postoperatively.
Minimum follow-up period of 1 year postoperatively.
incidence of acute rejection
Time Frame: Within 1 year postoperatively
Within 1 year postoperatively

Secondary Outcome Measures

Outcome Measure
Time Frame
Vascular complications
Time Frame: Within 1 year postoperatively
Within 1 year postoperatively
Biliary complications
Time Frame: Within 1 year postoperatively
Within 1 year postoperatively

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zhi-Jun Zhu

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2014

Primary Completion (Estimated)

December 31, 2028

Study Completion (Estimated)

December 31, 2029

Study Registration Dates

First Submitted

November 20, 2025

First Submitted That Met QC Criteria

November 27, 2025

First Posted (Actual)

December 9, 2025

Study Record Updates

Last Update Posted (Actual)

May 20, 2026

Last Update Submitted That Met QC Criteria

May 18, 2026

Last Verified

November 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • BFH20251127006

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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