Ultrasonographic Examination of Other Enthesitis Sites in Patients With Lateral Epicondylitis

December 18, 2025 updated by: İlker Yağcı, Marmara University

Ultrasonographic Examination of Other Enthesitis Sites in Patients With Lateral Epicondylitis: A Cross-Sectional Study

Lateral epicondylitis (LE) is the tendinopathy of the common extensor tendon. Although exact etiology remains unclear, it is believed to be caused by overuse.

Even though, genetics factor related to tendinopathies were defined accompanying tendinopathies in patients with LE is yet to be studied.

Madrid sonographic enthesitis index (MASEI) is an ultrasound based scoring system, developed for the evaluation of the enthesitis. Initially developed for ankylosing spondylitis, its usage has also become widespread in other musculoskeletal diseases.

The aim of this study is to calculate the MASEI score in patients diagnosed with LE, and compare it to healthy volunteers.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

60

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Turkey (Türkiye)
    • Maltepe
      • Istanbul, Maltepe, Turkey (Türkiye), 34844
        • Recruiting
        • Marmara University
        • Contact:
        • Sub-Investigator:
          • Arda Can Kasap, MD
        • Principal Investigator:
          • İlker Yağcı, Prof. M.D.
        • Sub-Investigator:
          • Naime Evrim Karadağ Saygı, Prof. M.D.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Patients presented to the outpatient clinic of Physical Medicine and Rehabilitation of Marmara University with elbow pain and diagnosed with lateral epicondylitis will be informed about the study. Willing patients will be enrolled after written consent is taken.

Control group will be chosen with volunteers, which have similar demographic characteristics.

Description

Inclusion Criteria:

  • Tenderness with palpation at the lateral epicondyle
  • Pain aggravated with resisted wrist extension

Exclusion Criteria:

  • History of rheumatologic diseases
  • History of elbow, knee or ankle surgery
  • History of corticosteroid injections on elbow, knee or ankle
  • History of peripheral neuropathy
  • Acute trauma

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Lateral Epicondylitis
Patients with lateral epicondylitis will be included in this group.
Diagnostic test: Madrid Sonographic Enthesitis Index
Patients will be evaluated with ultrasound at 6 different locations on each side, for total of 12 locations. These will be insertion points of triceps brachii tendon, quadriceps tendon, proximal and distal patellar tendons, achilles tendon and the plantar fascia. Evaluation parameters are the structure and thickness of the tendon, the presence of calcifications or enthesophytes, erosions in the bone, regional bursitis, and the presence of power-Doppler signal in the entheses.
Other Names:
  • MASEI
Control
Healthy volunteers with similar demographic characteristics will be enrolled to this group.
Diagnostic test: Madrid Sonographic Enthesitis Index
Patients will be evaluated with ultrasound at 6 different locations on each side, for total of 12 locations. These will be insertion points of triceps brachii tendon, quadriceps tendon, proximal and distal patellar tendons, achilles tendon and the plantar fascia. Evaluation parameters are the structure and thickness of the tendon, the presence of calcifications or enthesophytes, erosions in the bone, regional bursitis, and the presence of power-Doppler signal in the entheses.
Other Names:
  • MASEI

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Madrid Sonographic Enthesitis Index
Time Frame: At enrollment
Patients will be evaluated with ultrasound at 6 different locations on each side, for total of 12 locations. At each location; structure and thickness of the tendon, the presence of calcifications or enthesophytes, erosions in the bone, regional bursitis, and the presence of power-Doppler signal will be noted. Each parameter has a point of its own. Points obtained from each parameter will be added and total MASEI score (0-136) will be calculated. Higher scores indicate the presence of enthesitis.
At enrollment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Marmara University

Investigators

  • Principal Investigator: İlker Yağcı, Prof. Dr., Acıbadem Ataşehir Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 1, 2025

Primary Completion (Estimated)

January 31, 2026

Study Completion (Estimated)

January 31, 2026

Study Registration Dates

First Submitted

December 18, 2025

First Submitted That Met QC Criteria

December 18, 2025

First Posted (Estimated)

January 2, 2026

Study Record Updates

Last Update Posted (Estimated)

January 2, 2026

Last Update Submitted That Met QC Criteria

December 18, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 09.2025.25-0844

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Due to legal restrictions, all data will be anonymized. Individual participant data won't be shared to third parties.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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