Hybrid Stroke Rehab With Mirror Priming

December 23, 2025 updated by: Yi-chun Li, I-Shou University

Hybrid Stroke Rehabilitation With Mirror Priming

This trial aims to examine the effects of enhanced mirror priming, overcoming the limitations of traditional mirror therapy, to achieve optimization and personalized intervention.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

81

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Taiwan
    • Yanchao District
      • Kaohsiung City, Yanchao District, Taiwan, 82445
        • Recruiting
        • E-DA Hospital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  1. A first-ever unilateral stroke ≥3 months
  2. Age between 20 and 80 years
  3. Baseline Fugl-Meyer Assessment Upper Extremity (FMA-UE) score >10
  4. No severe spasticity in any joints of the affected arm
  5. Ability to follow the instructions
  6. No participation in other studies during the study period
  7. Willingness to provide informed written consent.

Exclusion Criteria:

1. Serious medical problems or poor physical conditions that might be detrimental to study participation.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: High-dose enhanced mirror priming group
Behavioral: Mirror priming
During the mirror priming process, the movement images of the participant's unaffected limb are mirrored to the affected side to provide visual feedback.
Behavioral: Conventional therapy
During conventional therapy, the participants typically receive interventions targeting the upper and lower limbs in addition to cognitive practice.
Experimental: Low-dose enhanced mirror priming group
Behavioral: Mirror priming
During the mirror priming process, the movement images of the participant's unaffected limb are mirrored to the affected side to provide visual feedback.
Behavioral: Conventional therapy
During conventional therapy, the participants typically receive interventions targeting the upper and lower limbs in addition to cognitive practice.
Active Comparator: Active control group
Behavioral: Conventional therapy
During conventional therapy, the participants typically receive interventions targeting the upper and lower limbs in addition to cognitive practice.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Fugl-Meyer Assessment
Time Frame: Baseline, 2 weeks, 4 weeks, 1 month, and 3 months post-intervention.
Baseline, 2 weeks, 4 weeks, 1 month, and 3 months post-intervention.

Secondary Outcome Measures

Outcome Measure
Time Frame
Grip and pinch power
Time Frame: Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Revised Nottingham Sensory Assessment
Time Frame: Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Berg Balance Scale
Time Frame: Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Montreal Cognitive Assessment
Time Frame: Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Motor Activity Log
Time Frame: Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Baseline, 4 weeks, 1 month, and 3 months post-intervention.
ABILHAND Questionnaire
Time Frame: Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Chedoke Arm and Hand Activity Inventory
Time Frame: Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Stoke Impact Scale
Time Frame: Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Stroke Self-Efficacy Questionnaire
Time Frame: Baseline, 4 weeks, 1 month, and 3 months post-intervention.
Baseline, 4 weeks, 1 month, and 3 months post-intervention.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

I-Shou University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

December 30, 2025

Primary Completion (Estimated)

December 31, 2030

Study Completion (Estimated)

December 31, 2030

Study Registration Dates

First Submitted

December 23, 2025

First Submitted That Met QC Criteria

December 23, 2025

First Posted (Actual)

January 7, 2026

Study Record Updates

Last Update Posted (Actual)

January 7, 2026

Last Update Submitted That Met QC Criteria

December 23, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • ISU-OT-Li-02

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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