Investigation of Hemodynamics and Radiomics Based on High Resolution Magnetic Resonance Imaging for Predicting the Outcomes of Intracranial Dissecting Aneurysm

January 4, 2026 updated by: Li wenqiang, Beijing Neurosurgical Institute
This study aims to conduct a comprehensive analysis by integrating clinical factors, aneurysm morphological characteristics, and factors reflecting pathophysiological processes (such as hemodynamic and radiomics features), in order to explore the hemodynamic mechanisms associated with the progression of intracranial dissecting aneurysms. Furthermore, artificial intelligence algorithms will be employed to develop and validate an intelligent risk prediction model for the progression and outcomes of intracranial dissecting aneurysms.

Study Overview

Status

Active, not recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

208

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Beijing Municipality
      • Beijing, Beijing Municipality, China, 107000
        • Beijing Tiantan Hospital, Capital Medical University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

The target population consists of patients with intracranial artery dissection (IAD) who received care at the study institution between 2015 and 2025. Eligible participants are adults aged 18-80 years with IAD confirmed by both digital subtraction angiography (DSA) and high-resolution MRI (HR-MRI) according to the imaging diagnostic criteria proposed in the Chinese expert consensus on intracranial artery dissection. Participants are managed with conservative treatment and undergo follow-up, and they provide written informed consent. Key exclusions include arteritis, fibromuscular dysplasia, iatrogenic or traumatic pseudoaneurysm; contraindications to MRI or cerebral angiography (e.g., implanted metallic foreign bodies, claustrophobia, or iodinated contrast allergy); extracranial dissection extending intracranially or concomitant intracranial atherosclerotic plaque in the affected vessel; refusal of MRI; severe comorbidities with an expected survival of less than 2 years; or absence of

Description

Inclusion Criteria:

  1. Intracranial dissecting aneurysm clearly diagnosed by DSA and high-resolution MRI imaging (according to the imaging diagnostic criteria proposed in the Chinese Expert Consensus on Imaging Diagnosis of Intracranial Arterial Dissection)
  2. patients managed with conservative treatment and follow-up
  3. patients who agree and sign a written informed consent form

Exclusion Criteria:

  1. Arteritis, fibromuscular dysplasia, iatrogenic or traumatic pseudoaneurysms
  2. Contraindications to MRI examination (such as claustrophobia or metallic implants), or contraindications to cerebral angiography (such as iodine contrast allergy)
  3. Dissecting aneurysms extending from the extracranial segment to the intracranial segment, or cases with concomitant intracranial atherosclerotic plaques in the affected vessels
  4. Patients who refuse MRI examination
  5. Patients with severe comorbid diseases and an expected survival time of less than 2 years due to these conditions
  6. Patients without follow-up HR-MRI imaging for any reason

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Control Group (Non-progression Group)
Imaging progression of intracranial dissecting aneurysms during follow-up
Experimental Group (Progression Group)
Imaging progression of intracranial dissecting aneurysms during follow-up

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Progression of intracranial dissecting aneurysms
Time Frame: From enrollment to 12 months of follow-up
From enrollment to 12 months of follow-up

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Beijing Neurosurgical Institute

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2023

Primary Completion (Estimated)

December 31, 2027

Study Completion (Estimated)

December 31, 2027

Study Registration Dates

First Submitted

January 4, 2026

First Submitted That Met QC Criteria

January 4, 2026

First Posted (Estimated)

January 12, 2026

Study Record Updates

Last Update Posted (Estimated)

January 12, 2026

Last Update Submitted That Met QC Criteria

January 4, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • KY2024-315-02

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

To protect patient privacy, the decision was made not to share the data.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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