Effects of Sulforaphane Supplementation on Athletic Performance

January 6, 2026 updated by: Filipe Silvano Pinto Maia, University of Maia

Effects of Sulforaphane Supplementation on Athletic Performance: a Double-blinded Randomized Crossover Study

Considering the promising effects observed and the scarce and incipient scientific background of SFN in sports, the present study aims to evaluate the effects of SFN supplementation on fatigue, EIMD and recovery in trained individuals. In particular, outcomes such as time to exhaustion (TTE), and perceptual questionnaires of muscle soreness, recovery, and fatigue will be assessed, aiming to explore the effectiveness of SFN.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

20

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Physically active individuals (engaging in exercise 3 or more times per week)

Exclusion Criteria:

  • Individuals that experience musculoskeletal injuries or have experienced in the past 3 months

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Sulforaphane
Sulforaphane supplementation (Nomio)
Other: Fatigue protocol
Fatigue protocol comprising 6 sets of 30 seconds at 120% of velocity of maximal oxygen consumption
Placebo Comparator: Placebo
Placebo intervention
Other: Fatigue protocol
Fatigue protocol comprising 6 sets of 30 seconds at 120% of velocity of maximal oxygen consumption

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
time to exhaustion
Time Frame: 24 hours
24 hours

Secondary Outcome Measures

Outcome Measure
Time Frame
Rating of Fatigue Scale
Time Frame: Baseline, 30 minutes, 24 hours
Baseline, 30 minutes, 24 hours
Total Quality Recovery Scale
Time Frame: Baseline, 30 minutes, 24 hours
Baseline, 30 minutes, 24 hours
Muscle soreness (Visual analogue scale)
Time Frame: Baseline, 30 minutes, 24 hours
Baseline, 30 minutes, 24 hours
Rating of perceived exertion scale
Time Frame: 30 minutes
30 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Maia

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

January 2, 2026

Primary Completion (Estimated)

April 1, 2026

Study Completion (Estimated)

May 1, 2026

Study Registration Dates

First Submitted

December 20, 2025

First Submitted That Met QC Criteria

January 6, 2026

First Posted (Actual)

January 15, 2026

Study Record Updates

Last Update Posted (Actual)

January 15, 2026

Last Update Submitted That Met QC Criteria

January 6, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SFN_001

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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