Longitudinal Prospective Study of Maternal and Child Nutrition in Arkansas

Longitudinal Prospective Study of Maternal and Child Nutrition in Arkansas - The Thrive Study

The investigators want to learn how women's diets may impact breastfeeding outcomes. This study will help the investigators learn more about how diet and social factors like food access may impact mothers' health, breastfeeding, and their baby's health. Participants will attend a visit before birth, then 11 visits as their baby grows up. All visits will be remote using RedCap, phone or video call, text messaging or any other communication modalities of preference to the participant. The investigators will ask for personal information about participants' family, home, and finances, health literacy, medical history, current medications, pregnancy complications, mental health (depression, quality of life), confidence in breastfeeding, eating habits, and plan to feed their baby. After childbirth, the investigators will ask about participants' delivery and child's health, and request access to their child's medical records. Across all visits, the investigators will ask participants to measure their weight, height, blood pressure, activity and sleep, and child's length; the investigators will also ask them to ship urine, stool, and breast milk samples. The investigators will obtain a 24-hour feeding log for the child, as well as a log of what the mother ate and drank over 24 hours.

Study Overview

• Status: Not yet recruiting
• Conditions: Maternal Health; Infant Nutrition; Maternal Nutrition; Pediatric Nutrition

• Study Type: Observational
• Enrollment (Estimated): 125

Contacts and Locations

Study Locations

• United States
  • Arkansas
    • Little Rock, Arkansas, United States, 72202
      • Arkansas Children's Research Institute
      • Contact: Audrey Martinez, PhD, RD; Phone Number: 5013642785; Email: martinezae@archildrens.org
      • Contact: Email: andresaline@uams.edu
      • Principal Investigator: Aline Andres, PhD, RD, CLC

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

This longitudinal prospective study will recruit a cohort representative of the state of Arkansas We will achieve this goal by designing a study with assessments that are fully developed for remote data and sample collections.

Description

Inclusion Criteria:

• At least 30 weeks pregnant
• Ability to engage in study procedures throughout the first 12 months postpartum

Exclusion Criteria:

• None

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Maternal dietary intake	24 hour dietary recall using ASA24	Third trimester of pregnancy and 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18 and 24 months postpartum
Child dietary pattern	24 hour recall using NDSR	0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18 and 24 month of age
Breastfeeding outcomes	Exclusivity, duration and mixed feeding	0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18 and 24 month postpartum

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Maternal weight	Smart scale	Third trimester and 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18 and 24 month postpartum
Human milk composition	macronutrients, micronutrients and non-nutritive components	0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18, 24 month postpartum or as long as lactating
Blood pressure	Smart device, at home collection	Third trimester and 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18, 24 month postpartum
Physical activity	Accelerometry	Third trimester and 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18, 24 months postpartum

Collaborators and Investigators

• Sponsor: Arkansas Children's Hospital Research Institute

Study record dates

Study Major Dates

• Study Start (Estimated): May 1, 2026
• Primary Completion (Estimated): June 1, 2029
• Study Completion (Estimated): June 1, 2029

Study Registration Dates

• First Submitted: March 10, 2026
• First Submitted That Met QC Criteria: March 13, 2026
• First Posted (Actual): March 17, 2026

Study Record Updates

• Last Update Posted (Actual): March 17, 2026
• Last Update Submitted That Met QC Criteria: March 13, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: 299710

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL; ICF

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No