AC Deflation in Descemet's Membrane Detachment

January 16, 2026 updated by: Ahmed Maher Khalafallah, Minia University

Effect of Anterior Chamber Deflation Before Reduction of a Detached Descemet's Membrane

using a relatively new technique to manage post-cataract surgery complication and measuring its efficacy

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

50

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Egypt
    • None Selected
      • Minya, None Selected, Egypt, 61111

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Patients with post cataract surgery DM detachment diagnosed within 1st week postoperatively.
  • Patient age ranges from 50 to 70 years old.

Exclusion Criteria:

  • Less than one third of Descemet's Membrane is included.
  • Post-operative infection or severe inflammation.
  • Patient with pre-existing glaucoma.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: will undergo direct intracameral air injection
Procedure: group A will undergo direct intracameral air injection and group B will undergo anterior chamber deflation then intracameral air injection
a group will undergo direct intracameral air injection and another group will undergo anterior chamber deflation then intracameral air injection
Other: will undergo anterior chamber deflation then intracameral air injection
Procedure: group A will undergo direct intracameral air injection and group B will undergo anterior chamber deflation then intracameral air injection
a group will undergo direct intracameral air injection and another group will undergo anterior chamber deflation then intracameral air injection

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Rate of complete anatomical reduction of DMD on ASOCT at the 1-week visit.
Time Frame: 1 week
1 week

Secondary Outcome Measures

Outcome Measure
Time Frame
. Time to complete anatomical reduction (days)
Time Frame: 1 month
1 month

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Minia University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 20, 2025

Primary Completion (Estimated)

January 1, 2026

Study Completion (Estimated)

February 1, 2026

Study Registration Dates

First Submitted

December 29, 2025

First Submitted That Met QC Criteria

January 16, 2026

First Posted (Actual)

January 23, 2026

Study Record Updates

Last Update Posted (Actual)

January 23, 2026

Last Update Submitted That Met QC Criteria

January 16, 2026

Last Verified

July 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • 592\7\2025

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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