ICU Admission Diagnoses and ICU Mortality

February 2, 2026 updated by: Mehmet Akif Yilmaz, Ataturk University

Association of Admission Syndromic Diagnoses With ICU Mortality in a Mixed Adult Intensive Care Unit: Retrospective Cohort

This retrospective cohort study will evaluate whether syndromic clinical diagnoses present at ICU admission are associated with ICU mortality, independent of physiologic severity scores. Adult patients admitted to a tertiary mixed ICU during 2025 will be assessed.

Study Overview

Status

Completed

Conditions

Detailed Description

Data will be obtained retrospectively from the hospital information system and ICU clinical records. Variables will be recorded based on the first 24 hours after ICU admission. Demographics, admission characteristics, comorbidities, severity scores (APACHE II, SAPS, SOFA), and admission syndromic diagnoses (e.g., sepsis/septic shock, acute respiratory failure, ARDS, MODS) will be collected. The primary outcome is ICU mortality; secondary outcomes include ICU length of stay and ICU discharge disposition.

Study Type

Observational

Enrollment (Actual)

1248

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Adult patients admitted to the tertiary mixed ICU of Atatürk University Faculty of Medicine (Department of Anesthesiology and Reanimation) between January 1 2024 and December 31 2025. Data will be collected retrospectively from hospital information systems and ICU records, based on the first 24 hours after ICU admission.

Description

Inclusion Criteria:

  • Adult patients (≥18 years) admitted to the ICU between January 1, 2025 and December 31, 2025.
  • If a patient has more than one ICU admission during the study period, only the first ICU admission will be included.

Exclusion Criteria:

  • ICU stay <24 hours.
  • Missing essential data preventing assessment of the primary outcome (ICU mortality) and/or calculation of severity scores (APACHE II, SAPS, SOFA).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Adult ICU admissions (2025)
Adult patients (≥18 years) admitted to a tertiary mixed intensive care unit between January 1, 2025 and December 31, 2025. For patients with multiple ICU admissions, only the first ICU admission will be included. Data will be abstracted retrospectively from electronic medical records and ICU charts; variables will be recorded based on the first 24 hours after ICU admission.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
ICU mortality
Time Frame: From ICU admission until ICU discharge (end of index ICU stay), assessed up to 90 days
Death occurring during the index ICU stay (ICU mortality), abstracted from electronic medical records.
From ICU admission until ICU discharge (end of index ICU stay), assessed up to 90 days

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
ICU length of stay (LOS)
Time Frame: From ICU admission to ICU discharge (index ICU stay), assessed at ICU discharge (up to 90 days)
ICU length of stay (days) during the index ICU admission, calculated as the difference between ICU admission and ICU discharge timestamps in the electronic medical record.
From ICU admission to ICU discharge (index ICU stay), assessed at ICU discharge (up to 90 days)
ICU discharge disposition
Time Frame: At ICU discharge (index ICU stay; assessed at the time of ICU discharge in the medical record, up to 90 days)
Disposition at ICU discharge categorized as: death in ICU, transfer to hospital ward, or transfer to another facility; determined from the ICU discharge documentation in the electronic medical record.
At ICU discharge (index ICU stay; assessed at the time of ICU discharge in the medical record, up to 90 days)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ataturk University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

  • Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA. 1993 Dec 22-29;270(24):2957-63. doi: 10.1001/jama.270.24.2957. Erratum in: JAMA 1994 May 4;271(17):1321. PMID: 8254858.
  • Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985 Oct;13(10):818-29. PMID: 3928249.
  • Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013 Nov 21;369(21):2063. doi: 10.1056/NEJMc1312359. PMID: 24256390
  • Vincent JL, Marshall JC, Namendys-Silva SA, François B, Martin-Loeches I, Lipman J, Reinhart K, Antonelli M, Pickkers P, Njimi H, Jimenez E, Sakr Y; ICON investigators. Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. Lancet Respir Med. 2014 May;2(5):380-6. doi: 10.1016/S2213-2600(14)70061-X. Epub 2014 Apr 14. PMID: 24740011

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 30, 2026

Primary Completion (Actual)

February 2, 2026

Study Completion (Actual)

February 2, 2026

Study Registration Dates

First Submitted

January 8, 2026

First Submitted That Met QC Criteria

January 22, 2026

First Posted (Actual)

January 27, 2026

Study Record Updates

Last Update Posted (Actual)

February 4, 2026

Last Update Submitted That Met QC Criteria

February 2, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • ICU-RETRO-2025
  • 2026/1 (Atatürk University Clinical Research Ethics Committee)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Individual participant data will not be shared because the dataset is derived from retrospective hospital records and contains potentially identifiable information.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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