Preemptive Analgesia in Laparoscopic Hysterectomy

The Effects of Preemptive Analgesic Protocols on Perioperative Pain Management in Laparoscopic Hysterectomy: A Prospective Observational Study

The aim of this study is to evaluate the effects of ibuprofen and paracetamol administered for pre-emptive analgesia to patients undergoing laparoscopic hysterectomy on pain scores during the first 24 hours postoperatively, the amount of opioids consumed postoperatively, and adverse effects such as postoperative nausea and vomiting.

Study Overview

• Status: Completed
• Conditions: Postoperative Analgesia; Laparoscopic Hysterectomy
• Intervention / Treatment: Drug: Ibuprofen; Drug: Parasetamol

Detailed Description

Patients who undergo laparoscopic hysterectomy surgery are administered certain treatment methods for postoperative analgesia. These applications are a routine part of the procedure. They are medically and ethically necessary. Postoperative analgesia applications are initiated during the intraoperative process and continued during the postoperative process. The analgesia protocol to be used is determined by the patient's characteristics and the anaesthetist's experience. Multimodal analgesia protocols are scientifically accepted methods. Preemptive analgesia, a method used for pain control that reduces the severity of pain caused by analgesics, delays the initial need for analgesia, and reduces the need for painkillers, is one of these protocols. This method, applied before surgical incision or tissue damage, covers a wide range, from first-line analgesics such as paracetamol and ibuprofen to opioids and peripheral and central blocks. The aim of this study is to evaluate the effects of ibuprofen and paracetamol administered for preemptive analgesia in patients undergoing laparoscopic hysterectomy on pain scores in the first 24 hours postoperatively, the amount of opioids consumed postoperatively, and adverse effects such as postoperative nausea and vomiting.

• Study Type: Observational
• Enrollment (Actual): 70

Contacts and Locations

Study Locations

• Turkey (Türkiye)
  • Giresun, Turkey (Türkiye)
    • Operating Room at the Giresun Obstetrics and Gynecology and Pediatrics Training and Research Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Female patients aged 18 to 70 who are scheduled to undergo laparoscopic hysterectomy surgery.

Description

Inclusion Criteria:

• Aged 18-70
• ASA I-III patients
• Patients undergoing elective laparoscopic hysterectomy surgery

Exclusion Criteria:

• Emergency surgery
• Patients who require conversion to abdominal hysterectomy during the intraoperative period
• Those with severe liver or kidney failure, a history of long-term nonsteroidal anti-inflammatory and opioid analgesic use
• Those with a history of gastrointestinal bleeding, peptic ulcer or inflammatory bowel disease, diabetes or other neuropathic diseases
• Patients unable to use patient-controlled analgesia (PCA) devices

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Group İ (İbuprofen); Patients who are administered ibuprofen pre-emptively analgesia, in accordance with routine clinical practice.	Drug: Ibuprofen; Administered as part of standard institutional anesthesia practice.; Other Names: ibuprofen 400 mg
Group P (Parasetamol); Patients who are administered parasetamol pre-emptively analgesia, in accordance with routine clinical practice.	Drug: Parasetamol; Administered as part of standard institutional anesthesia practice.; Other Names: parasetamol 1 g

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Postoperative analgesia	Postoperative analgesia was assessed by measuring postoperative pain intensity using the Visual Analog Scale (VAS) and by recording cumulative opioid or rescue analgesic consumption. The Visual Analog Scale ranges from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Lower pain scores and reduced analgesic requirements were considered indicators of better postoperative analgesia.	from the end of surgery up to 24 hours postopeartively

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
İntraoperative analgesia	Intraoperative analgesia was assessed by evaluating hemodynamic responses to surgical stimuli, including changes in heart rate and mean arterial pressure, as well as the requirement for additional intraoperative analgesic agents. Stable hemodynamic parameters and a reduced need for supplemental analgesia were considered indicators of adequate intraoperative analgesia.stimuli, including changes in heart rate and mean arterial pressure, as well as the requirement for additional intraoperative analgesic agents. Stable hemodynamic parameters and reduced need for supplemental analgesia were considered indicators of adequate intraoperative analgesia.	During surgery (from skin incision until the end of surgery)
Intraoperative hemodynamic instability	Intraoperative hemodynamic instability was assessed by continuous monitoring of heart rate and mean arterial pressure throughout the surgical procedure. Hemodynamic instability was defined as the occurrence of hypotension, hypertension, bradycardia, or tachycardia based on deviations from baseline values.	During surgery (from induction of anesthesia until the end of surgery)

Collaborators and Investigators

• Sponsor: Giresun University

Study record dates

Study Major Dates

• Study Start (Actual): February 2, 2026
• Primary Completion (Actual): April 1, 2026
• Study Completion (Actual): May 1, 2026

Study Registration Dates

• First Submitted: January 27, 2026
• First Submitted That Met QC Criteria: February 3, 2026
• First Posted (Actual): February 11, 2026

Study Record Updates

• Last Update Posted (Actual): May 18, 2026
• Last Update Submitted That Met QC Criteria: May 14, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Organic Chemicals; Carboxylic Acids; Acids, Carbocyclic; Phenylpropionates; Ibuprofen
• Other Study ID Numbers: GOKAEK 2025/13/9

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Individual participant data will not be shared due to ethical and confidentiality considerations

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No