Comparison Between Two Drugs in Sedation of Upper GI Endoscopy

February 14, 2026 updated by: Zagazig University

Ketamine - Dexmedetomidine(Ketodex) Versus Propofol -Midazolam for Sedation in Patients Undergoing Upper Gastrointestinal Endoscopy

The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs

Secondary outcome :

  • Recovery time :is the time to reach score 2 of modified Ramsay sedation score starting from injecting bolus dose of study drugs .
  • Hemodynamics (MAP,HR) & oxygen saturation
  • Drug side effects (nausea,vomitting,agitation)
  • Endoscopist satisfaction

Study Overview

Status

Not yet recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

52

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

Adult patients not more than 60 years old with BMI < 35 kg/m2

Description

Inclusion Criteria

  • Patient acceptance
  • Adults aged 21-60 years.
  • Both sexes
  • BMI<35 kg/m2
  • ASA physical status :I& II
  • Patients Undergoing Gastrointestinal endoscopy
  • Duration <30mintues

Exclusion Criteria:

  • • Known allergy to any of the study drugs

    • Unstable Cardiovascular disease
    • Moderate to severe respiratory diseases

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Ketamine dexmetamodine and propofol midazolam

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Comparison between time of sedation between ketamine Dexametomidine and propofol midazolam in sedation of GI endoscopy
Time Frame: Baseline
Time of sedation :is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs
Baseline
Comparison time of sedation between ketamine Dexametomidine and propofol midazolam in sedation of GI endoscopy
Time Frame: Baseline
Time of sedation:is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs
Baseline
Comparison of time of sedation between ketamine Dexametomidine g
Time Frame: Basline
• Time of sedation :is the time to reach score 5 of modified Ramsay sedation score starting from injecting bolus dose of study drugs .
Basline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zagazig University

Investigators

  • Principal Investigator: Doaa Mohamed Farid, MD, Doaa mohamed Farid
  • Study Director: Rehab Abdalla Wahdan, MD, Rehab Abdalla Wahdan
  • Principal Investigator: Olfat Monium Abraham, MD, Olfat abdelmonium Ebrahim

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

March 1, 2026

Primary Completion (Estimated)

May 2, 2026

Study Completion (Estimated)

May 2, 2026

Study Registration Dates

First Submitted

February 14, 2026

First Submitted That Met QC Criteria

February 14, 2026

First Posted (Actual)

February 20, 2026

Study Record Updates

Last Update Posted (Actual)

February 20, 2026

Last Update Submitted That Met QC Criteria

February 14, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • Sedation in GI endoscopy

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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