Effect of Optokinetic Stimulation on Spatial Neglect and Postural Stability in Patients With Stroke

February 14, 2026 updated by: Abeer Abdelmoghney Mohamed, Cairo University
The purpose of this study is to investigate the efficacy of optokinetic stimulation in stroke patients by examining its effects on spatial neglect, static balance, dynamic balance, and weight-bearing symmetry.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

In stroke patients the presence of spatial neglect predicts poor outcome in functional recovery, entailing a longer time of hospitalization, greater functional dependency, increased risk of falls and a long-term disability in Activities of Daily Living (ADL). This results in an overall increase of costs for the health system.

Spatial neglect patients' performance in self-care and household is usually compromised. Those patients had more problems in performing self-care and household tasks than non-spatially neglected patients. For example, spatial neglect patients forgot or could not find objects at one side when dressing or in the kitchen and had difficulty eating or using devices. VSN severity had a negative impact on the performance of ADL. Spatial neglect had a negative impact on walking and wheelchair navigation. Spatial neglect had a negative impact on exercise such as walking and jogging .

Patients with spatial neglect had an increased weight-bearing asymmetry favouring the non-paretic leg and increased mediolateral CoP excursions while standing. However, upright standing is an inherently more demanding posture owing to the height of the center of mass relative to the base of support.

Because of all those effects of spatial neglect on outcomes, it is a necessity to engage more neurological rehabilitative procedures focusing on neglect and its complications. One of the treatments used for neglect is optokinetic stimulation (OKS).

The vestibular apparatus is the primary organ of balance which is used mainly during motion when compared to somatosensation. Optokinetic stimulation is known to stimulate areas of the brain such as the brain stem and cerebellum that immediately process balance signals from the vestibular apparatus before they are transmitted to the cerebral cortex via the thalamus. Optokinetic chart stimulation has been reported to restore voluntary movement and mobility in an acute hemorrhagic stroke as well as restore postural control and independent mobility in an acute, ataxic, posterior temporal parietal ischemic stroke.

So, this study will be conducted to investigate the effect of optokinetic stimulation on neglect and balance measures in stroke patients rehabilitation.

Study Type

Interventional

Enrollment (Estimated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Nagwa Ibrahim Rehab, PhD

Study Contact Backup

Study Locations

  • Egypt
      • Banī Suwayf, Egypt
        • Nahda University
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Patient's age ranges from 50 to 65 years referred by neurologist.
  • Patient's will be diagnosed as stroke in the subacute stage
  • Patients will suffer from spatial neglect resulting from the stroke that screened by albert's test.
  • Patients are medically stable and able to understand and follow instructions.

Exclusion Criteria:

  • There is any previous neurological disability
  • There is general unstable conditions, history of epilepsy, cardiac pacemakers
  • There is sever cognitive disorder
  • There is visual field deficit

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Optokinetic stimulation + Traditional therapy
Patients in this group will receive optokinetic stimulation and traditional therapy, twice weekly over a period of 10 weeks.
Other: Optokinetic stimulation
Patients will receive optokinetic stimulation (OKS) as an intervention for spatial neglect, based on observing moving visual stimuli to promote visual scanning of the neglected hemispace. With the patient properly positioned, the physiotherapist will apply virtual reality glasses supported by a mobile device displaying pre-prepared OKS videos. The videos will show vertical bars moving leftward at a fixed speed of 1 cm/s, with random color changes to maintain attention. Patients will be instructed to report each color change. OKS will be delivered in five 4-minute bouts separated by 1-minute rest intervals, totaling 20 minutes per session.
Other: Traditional therapy
All participants in both groups will receive a selected physical therapy program for 30 min per session to enhance balance for 10 weeks.
Sham Comparator: Sham optokinetic stimulation + Traditional therapy
Patients in this group will receive sham optokinetic stimulation and traditional therapy, twice weekly over a period of 10 weeks.
Other: Traditional therapy
All participants in both groups will receive a selected physical therapy program for 30 min per session to enhance balance for 10 weeks.
Other: Sham optokinetic stimulation
A static image consisting of black-and-white vertical bars will be projected for patients in this group. The bars will undergo random color changes similar to those used in the intervention group; however, no movement will be present.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Albert test
Time Frame: 10 weeks
It is the test used for screening of unilateral spatial neglect .the examiner asked to cross all the lines. The more un crossed lines the worst degree of spatial neglect.
10 weeks
Catherine bergego scale (CGS)
Time Frame: 10 weeks
It is a 4 point scale used to indicate the severity of neglect .the total score out of 30 . the higher scores indicate the more severe the spatial neglect
10 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Limit of stability (LOS)
Time Frame: 10 weeks
It measures the examiner ability to shift center of gravity in eight directions. Lower scores indicated lower abilities to maintain dynamic balance.
10 weeks
The Modified clinical test of sensory interaction on balance (m CTSIB)
Time Frame: 10 weeks
It measures sensory integration and its effect on stability and static balance. The higher scores indicates higher control.
10 weeks
Center of pressure
Time Frame: 10 weeks
It examiner would maintain his center of pressure in the center of illustrated figure on the screen of HUMAC system . the longer the patient can maintain static balance the more control and stability patient has.
10 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cairo University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

February 20, 2026

Primary Completion (Estimated)

May 5, 2026

Study Completion (Estimated)

May 15, 2026

Study Registration Dates

First Submitted

February 14, 2026

First Submitted That Met QC Criteria

February 14, 2026

First Posted (Actual)

February 20, 2026

Study Record Updates

Last Update Posted (Actual)

February 20, 2026

Last Update Submitted That Met QC Criteria

February 14, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • P.T.REC/012/005508

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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