Parasternal Block Added to Serratus Anterior Plane Block in Breast Reduction Surgery

February 19, 2026 updated by: emine bayraktar, Zonguldak Bulent Ecevit University

The Effect of Adding a Parasternal Intercostal Plane Block to a Serratus Anterior Plane Block on Postoperative Opioid Consumption in Breast Reduction Surgery

This study aims to evaluate the effect of adding a Superficial Parasternal Intercostal Plane Block (PIPB) to the Serratus Anterior Plane Block (SAPB) on postoperative pain control in patients undergoing breast reduction surgery under general anesthesia. Effective postoperative analgesia is essential to reduce opioid consumption and improve recovery.

All patients will receive standard general anesthesia. Patients will be allocated into three groups: a control group receiving no regional block, a group receiving SAPB alone, and a group receiving SAPB combined with PIPB. The primary outcome of the study is total opioid consumption within the first 24 hours after surgery. Secondary outcomes include postoperative pain scores, Quality of Recovery-15 (QoR-15) scores, and intraoperative remifentanil consumption.

The study aims to determine whether SAPB reduces postoperative opioid requirements compared to no block, and whether adding PIPB provides additional analgesic benefit by blocking the anterior cutaneous branches of the intercostal nerves. The findings may contribute to improving multimodal analgesia strategies in breast surgery.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

90

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey (Türkiye)
    • Maltepe
      • Zonguldak, Maltepe, Turkey (Türkiye)
        • Zonguldak Bulent Ecevit University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Female patients aged 18-65 years
  • Scheduled for elective breast reduction surgery under general anesthesia
  • American Society of Anesthesiologists (ASA) physical status I-III
  • Ability to understand the study and provide written informed consent

Exclusion Criteria:

  • Patient refusal

    • Known allergy to local anesthetics
    • Coagulopathy or ongoing anticoagulant therapy
    • Infection at the block site
    • Chronic opioid use or opioid dependence
    • Severe hepatic or renal insufficiency
    • Pregnancy or breastfeeding

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
No Intervention: control
patients receive standard general anesthesia
Active Comparator: Serratus Anterior Plane Block
patients receive an ultrasound guided anterior serratus plane block in addition to general anesthesia before surgery
Procedure: Serratus Anterior Plane Block (SAPB)
injection local anesthetic between 5th rib and serratus anterior muscle
Active Comparator: Serratus Anterior Plane Block + Parasternal Intercostal Plane Block
patients receive an ultrasound guided anterior serratus plane block combined with a parasternal plane block in addition to general anesthesia before surgery
Procedure: Serratus Anterior Plane Block (SAPB) and parasternal intercostal plane block
both injection local anesthetic between 5th rib and serratus anterior muscle at midaxillary line and between 4th costal cartilage and pectoralis major muscle at next to the sternum

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Total postoperative opioid consumption in the first 24 hours
Time Frame: First 24 hours after surgery
Total opioid consumption during the first 24 postoperative hours will be recorded and compared between the study groups.
First 24 hours after surgery

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Quality of recovery by using QoR-15 questionnaire
Time Frame: postoperative 24th hour
postoperative 24th hour
Pain Scores
Time Frame: postoperative 0, 1, 2, 6, 12, 24 th hour
using NRS Scale
postoperative 0, 1, 2, 6, 12, 24 th hour

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zonguldak Bulent Ecevit University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2024

Primary Completion (Actual)

August 25, 2025

Study Completion (Actual)

December 1, 2025

Study Registration Dates

First Submitted

February 19, 2026

First Submitted That Met QC Criteria

February 19, 2026

First Posted (Actual)

February 25, 2026

Study Record Updates

Last Update Posted (Actual)

February 25, 2026

Last Update Submitted That Met QC Criteria

February 19, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2024/08-6

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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