Intraoral vs Extraoral Cementation of Zirconia Bridges on Ti-Bases: Microstrain Evaluation

February 28, 2026 updated by: Marta Vallés Rodríguez, Universitat Internacional de Catalunya

Influence of Cementation Technique on Microstrain in Three-Unit Bridges on Ti-Bases Evaluated by Strain Gauges

This prospective clinical study compares two cementation techniques for implant-supported zirconia fixed partial dentures on titanium bases (Ti-bases): extraoral cementation performed on the working model and intraoral cementation performed chairside. Thirty clinical cases with two osseointegrated implants requiring a multi-unit zirconia restoration will be recruited at the UIC Dental Clinic. For each case, two restorations with identical design will be produced: one will be cemented extraorally (control) and an identical replica will be cemented intraorally (test). Micro-deformation will be assessed as peri-implant microstrain (µε) using a standardized strain-gauge setup and the same recording protocol for both techniques. The primary analysis compares microstrain between intraoral and extraoral cementation within each case; implant/prosthetic events will be recorded descriptively.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

This study will evaluate whether the cementation approach of zirconia restorations onto Ti-bases influences peri-implant strain. Two clinical workflows are compared: (1) extraoral cementation of the zirconia restoration to Ti-bases on the working model prior to delivery, and (2) intraoral chairside cementation of an equivalent restoration to Ti-bases using the same intended clinical seating conditions.

For each enrolled case, two restorations with the same design will be fabricated so that both cementation approaches can be assessed within the same case. After cementation, restorations will be evaluated using a standardized strain-gauge measurement setup on a model reproducing the clinical implant relationship, applying the same torque and recording procedure for both techniques.

All clinical procedures will be performed at the UIC Dental Clinic, and strain-gauge recordings will be performed at the collaborating center (Universidad Europea Miguel de Cervantes, UEMC) following a consistent protocol. Data will be handled using study codes, and only study-coded technical files will be shared with the collaborating center.

Study Type

Interventional

Enrollment (Estimated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: MARTA VALLES, DDS, PhD
  • Phone Number: +34 619747903
  • Email: mvalles@uic.es

Study Contact Backup

Study Locations

  • Spain
    • Barcelona
      • Sant Cugat del Vallès, Barcelona, Spain, 08195
        • Clínica Universitària d'Odontologia UIC Barcelona
        • Contact:
          • MARTA VALLES, Principal Investigator
          • Phone Number: +34 619747903
          • Email: mvalles@uic.es
        • Contact:
        • Principal Investigator:
          • MARTA VALLES, DDS, PhD
        • Sub-Investigator:
          • PATRICIA FREIRE, DDS

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Adults (≥18 years old) in good general health.
  • Presence of an edentulous space requiring rehabilitation with a three-unit implant-supported fixed bridge.
  • Presence of two already osseointegrated Essential Cone implants (Klockner) indicated for a three-unit implant-supported restoration in the edentulous area.
  • Ability and willingness to participate and attend study visits and follow-up.
  • Signed informed consent.

Exclusion Criteria:

  • ASA III or ASA IV.
  • Current or previous treatment with bisphosphonates.
  • Smoking >10 cigarettes/day.
  • Extraction in the study area <3 months before implant placement with incomplete healing.
  • Guided bone regeneration in the study area with <6 months of healing time.
  • Signs of active periodontal disease (e.g., poor plaque control and/or bleeding on probing above acceptable levels).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Non-Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Extraoral cementation (laboratory)
Three-unit zirconia bridge cemented to Ti-bases extraorally on the working model under standardized laboratory conditions. Strain-gauge evaluation is performed in the laboratory prior to prosthesis delivery.
Procedure: Extraoral cementation on Ti-bases
Extraoral (laboratory) cementation of a three-unit zirconia bridge to Ti-bases on the working model using a standardized protocol, with strain-gauge evaluation performed prior to prosthesis delivery.
Experimental: Intraoral cementation (chairside)
An identical three-unit zirconia bridge is cemented to Ti-bases intraorally following a standardized chairside protocol. The assembly is then removed and sent to the laboratory. Strain-gauge evaluation is performed approximately 1 week after intraoral cementation (7 ± 3 days).
Procedure: Intraoral cementation on Ti-bases
Intraoral (chairside) cementation of an identical three-unit zirconia bridge to Ti-bases following a standardized protocol. The assembly is removed and sent to the laboratory, where strain-gauge evaluation is performed approximately 1 week later (7 ± 3 days).

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Peri-implant microstrain (µε) measured by strain gauges
Time Frame: Pre-delivery (laboratory assessment) and ~1 week after intraoral cementation (7 ± 3 days).
Micro-deformation around implant replicas supporting a three-unit zirconia bridge on Ti-bases, recorded with bonded strain gauges and expressed as microstrain (µε). Measurements are obtained for both cementation techniques (extraoral vs intraoral) using the same standardized recording protocol. Measurements for the extraoral (control) restoration are recorded prior to delivery, and measurements for the intraoral (test) restoration are recorded approximately 1 week after chairside cementation once the restoration is received by the laboratory.
Pre-delivery (laboratory assessment) and ~1 week after intraoral cementation (7 ± 3 days).

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Difference in microstrain between techniques (paired within-case)
Time Frame: Pre-delivery (laboratory assessment) and ~1 week after intraoral cementation (7 ± 3 days).
Within each case, the difference in microstrain (µε) between intraoral and extraoral cementation is calculated using paired measurements to assess the magnitude and direction of the effect. Measurements for the extraoral (control) restoration are recorded prior to delivery, and measurements for the intraoral (test) restoration are recorded approximately 1 week after chairside cementation once the restoration is received by the laboratory.
Pre-delivery (laboratory assessment) and ~1 week after intraoral cementation (7 ± 3 days).

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Universitat Internacional de Catalunya

Investigators

  • Principal Investigator: MARTA VALLES, DDS, PhD, Universitat Internacional de Catalunya

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

March 1, 2026

Primary Completion (Estimated)

March 1, 2027

Study Completion (Estimated)

June 1, 2027

Study Registration Dates

First Submitted

February 23, 2026

First Submitted That Met QC Criteria

February 28, 2026

First Posted (Actual)

March 4, 2026

Study Record Updates

Last Update Posted (Actual)

March 4, 2026

Last Update Submitted That Met QC Criteria

February 28, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • REST-ECL-2025-06

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

IPD will not be shared because this is a single-center academic study with a small sample size, and the dataset includes detailed case-level clinical and technical measurements. We will report the results in aggregate form in publications.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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