Compare Between the Effect of CGF and PRF on Revascularization of Immature Roots of the Mandibular Permanent First Molar

March 4, 2026 updated by: Bothaina Ahmed, Minia University

Concentrated Growth Factor Versus Platelets-rich Fibrin in Revascularization of Immature Necrotic Mandibular First Permanent Molar.

in this study investigators do revascularization technique to promote root growth of immature mandibular first permanent molar by using CGF and PRF from blood sample of patients

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

children 6-8 yrs were selected for this study because the roots of mandibular first permanent molar is not completed. then access cavity is opened, irrigation protocol is applied, intracanal medication is applied and the cavity is sealed with temporary filling. after three weeks blood sample is obtained from patients to get CGF and PRF membranes. temporary filling is removed . intracanal medication is removed, over instrumentation is done to get some intracanal blood the wait tell blood clot is formed then CGF or PRF is applied on the clot the bio dentine is applied and cavity is sealed with composite restoration

Study Type

Interventional

Enrollment (Actual)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • Minya Governorate
      • Minya, Minya Governorate, Egypt, 2422998
        • Faculty of Dentistry Minya University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Children with immature necrotic lower fitrst permanent molar.
  • No history of repeated pathosis or cellulitis.
  • Patients accept the treatment modality.
  • Patient-free from systemic, allergic or genetic problems.

Exclusion Criteria:

  • Tooth mobility.
  • Teeth with non-restorable crowns.
  • Children with facial cellulitis
  • Children with draining fistula
  • Children with a history of recurrent preapical pathosis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: CGF and biodentine arm
(control group) Which CGF and bio-dentine are applied to the immature pulp of the first permanent molar
Biological: Revascularization/Conservative management
Compare the effect of CGF and PRF in the revascularization of immature mandibular first permanent molar using bio-dentine
Active Comparator: PRF and biodentine arm
PRF and bio-dentine are applied on immature pulp of first permanent molar
Biological: Revascularization/Conservative management
Compare the effect of CGF and PRF in the revascularization of immature mandibular first permanent molar using bio-dentine

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
root growth
Time Frame: 18 months
change root length
18 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Minia University

Investigators

  • Principal Investigator: Ahmed elheeny, professor of Pediatric and Com, unaffilliaed

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 10, 2025

Primary Completion (Estimated)

July 10, 2026

Study Completion (Estimated)

July 10, 2027

Study Registration Dates

First Submitted

February 13, 2026

First Submitted That Met QC Criteria

March 4, 2026

First Posted (Actual)

March 10, 2026

Study Record Updates

Last Update Posted (Actual)

March 10, 2026

Last Update Submitted That Met QC Criteria

March 4, 2026

Last Verified

August 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Bothaina A. Gado

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

CONCENTRATED GROWTH FACTOR VERSUS PLATELETS-RICH FIBRIN IN REVASCULARIZATION OF IMMATURE NECROTIC MANDIBULAR FIRST PERMANENT MOLAR

IPD Sharing Time Frame

2027

IPD Sharing Access Criteria

dental students and researchers in denta field

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Revascularization of Immature Young Permenant Teeth

Clinical Trials on Revascularization/Conservative management

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in New Zealand

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe