The Rapid Shallow Breathing Index (RSBI) is a Widely Used Predictor for Weaning Patients From Mechanical Ventilation This Study Aims to Determine the Predictive Value of RSBI Measurements for Extubation Success in Mechanically Ventilated ICU Patients

Rapid Shallow Index as Successfully Predictor of Outcome of Extubating

Early extubation in ICU patients is crucial for reducing complications of prolonged ventilation, including morbidity and mortality. The Rapid Shallow Breathing Index (RSBI) is a widely used predictor for weaning patients from mechanical ventilation. This study aims to determine the predictive value of RSBI measurements for extubation success in mechanically ventilated ICU patients

Study Overview

• Status: Recruiting
• Conditions: Failure of Extubation; Ventilated Patient in Intensive Care

Detailed Description

The extubation decision is a combined clinical judgment based on a passing Spontaneous Breathing Trial (SBT) and a Rapid Shallow Breathing Index (RSBI) value ≤ 105 breaths/min/L.combination of criteria (SBT + RSBI threshold) This approach is recommended to improve predictive accuracy, as neither SBT nor RSBI alone is perfectly reliable.

• Study Type: Observational
• Enrollment (Estimated): 70

Contacts and Locations

• Study Contact: Name: Sarah hamdy Elghareeb, MD; Phone Number: +201012434690; Email: sarahhamdy@med.asu.edu.eg

Study Locations

• Egypt
  • Abbasia
    • Cairo, Abbasia, Egypt, 1181
      • Recruiting
      • Ain Shams Hospital
      • Contact: Sarah Elghareeb; Phone Number: 01012434690; Email: sarahhamdy@med.asu.edu.eg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

mechnically ventilated patient eligable for extubation

Description

Inclusion Criteria:

• • Adults > 22 years.

  • Mechanically ventilated patients meeting extubation readiness:

    • FiO₂ ≤ 0.4, PEEP ≤ 8 cmH₂O, PaO₂/FiO₂ ≥ 200 mmHg.
    • Respiratory rate ≤ 35 breaths/min, pH > 7.30.
    • Hemodynamic stability (HR ≤ 120 bpm, SBP 90-160 mmHg).
    • Glasgow Coma Scale >10, adequate cough reflex.
  • Includes postoperative, elective/emergency reintubation, and tracheostomized patients.

Exclusion Criteria:

• Age <22 years.
• Refusal of informed consent.
• Altered mental status (e.g., traumatic brain injury).
• Hemodynamic instability or deep sedation (RASS ≤ -2).

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Extubation success (no reintubation/adjuvant support within 48h).	no reintubation or adjuvant oxygen therapy	48 hour

Collaborators and Investigators

• Sponsor: Ain Shams University

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2026

Study Registration Dates

• First Submitted: March 9, 2026
• First Submitted That Met QC Criteria: March 9, 2026
• First Posted (Actual): March 12, 2026

Study Record Updates

• Last Update Posted (Actual): March 13, 2026
• Last Update Submitted That Met QC Criteria: March 11, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Keywords: RSBI.VAP.success of extubation
• Other Study ID Numbers: FAMSU R39/2026

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: Yes