Reducing Lead Dust Exposure in Older Housing

Reducing Lead Dust Exposure and Childhood Blood Lead Levels in Older Housing in Michigan

The objective of this study is to assess the effectiveness of portable air filtration (PAF) for mitigating lead dust exposures and reducing childhood blood lead levels in older housing.

Study Overview

• Status: Recruiting
• Conditions: Elevated Blood Lead Levels; Exposure to Toxic Dust
• Intervention / Treatment: Other: portable air filtration systems

Detailed Description

In close collaboration with local health departments, this project will enroll 40 participants who (1) reside in housing built before 1970, and (2) have children under six years of age with blood lead levels (BLL) >5 μg/dL. Specific objectives include (1) assess reduction of Pb dust exposure via the intervention, (2) assess the ability of PAF to reduce childhood BLL indirectly via reductions in Pb dust exposure, and (3) develop evidence-based exposure reduction guidance for wider public use of PAF. The project team will measure Pb levels in (1) suspended dust, (2) floor dust, and (3) children's blood before the start and finish of the two-month-long intervention as well as at the midpoint.

• Study Type: Interventional
• Enrollment (Estimated): 40
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Tuan Nguyen, BS; Phone Number: 517-884-2043; Email: nguye620@msu.edu
• Study Contact Backup: Name: Masako Morishita, PhD; Phone Number: 517-884-0463; Email: tomoko@msu.edu

Study Locations

• United States
  • Michigan
    • East Lansing, Michigan, United States, 48824
      • Recruiting
      • Michigan State University
      • Contact: Tuan Nguyen, BS; Phone Number: 517-884-2043; Email: nguye620@msu.edu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• child under seven years of age with BLL >5 µg/dL,
• child must reside in housing built before 1978, and
• child must sleep at home during participation in the two month-long study.

Exclusion Criteria:

• anything in child's health history that could affect the study results, or
• any circumstance that could interfere with guardian's/parent's ability to consent and/or participate in the study.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: air filtration systems; Portable air filtration units will be kept running in homes for two months.	Other: portable air filtration systems; Two portable air filtration units placed in subjects' homes (one in child's bedroom and one in living room) will be kept running for two months.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in blood lead level	change in blood lead level (in ug/dL).	After two months at the end of the intervention

Collaborators and Investigators

• Sponsor: Michigan State University

Study record dates

Study Major Dates

• Study Start (Actual): December 1, 2022
• Primary Completion (Estimated): July 31, 2026
• Study Completion (Estimated): November 30, 2026

Study Registration Dates

• First Submitted: May 2, 2023
• First Submitted That Met QC Criteria: March 17, 2026
• First Posted (Actual): March 20, 2026

Study Record Updates

• Last Update Posted (Actual): March 20, 2026
• Last Update Submitted That Met QC Criteria: March 17, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: MILTS0025-21

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No