The Effect of Magnesium on Post-spinal Headaches

April 1, 2026 updated by: Emine Yilmaz Guler, Haseki Training and Research Hospital

The Effect of Intravenous Magnesium Sulphate on the Development of Post-Spinal Headache Following Caesarean Section Under Spinal Anaesthesia: A Retrospective Cohort Study

This retrospective cohort study aims to assess the effect of the use of magnesium sulphate in routine clinical practice on the development of post-dural puncture headache in patients undergoing spinal anaesthesia

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

300

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Turkey (Türkiye)
    • Sultangazi
      • Istanbul, Sultangazi, Turkey (Türkiye)
        • Haseki Training and Research Hospital
        • Contact:
        • Principal Investigator:
          • Emine Yılmaz Güler, Anesthesiologist

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

In this study, which is designed as a retrospective cohort study, the records of all patients who underwent caesarean section under spinal anaesthesia at our hospital between 1 January 2025 and 31 December 2025 and who met the inclusion criteria will be reviewed.

Description

Inclusion Criteria:

  • • Patients aged 18-45

    • Patients who underwent spinal anaesthesia for elective caesarean section
    • Patients with an ASA physical status score of I-III
    • Patients in whom a 25G or 27G pencil-point needle was used for spinal anaesthesia
    • Patients with complete medical records

Exclusion Criteria:

  • • Patients undergoing emergency surgery

    • Patients with a history of chronic headaches
    • Patients who have undergone unsuccessful spinal anaesthesia or multiple attempts
    • Patients who have undergone combined spinal-epidural anaesthesia
    • Patients with a contraindication to magnesium sulphate
    • Patients with insufficient medical records

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
administered intravenous magnesium
Other: Magnesium
Post-spinal headache in patients receiving magnesium
without intravenous magnesium
Other: Magnesium
Post-spinal headache in patients receiving magnesium

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Incidence of post-spinal headache
Time Frame: 1. day
the number of people who develop a headache following spinal anaesthesia
1. day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Haseki Training and Research Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

  • Uppal V, Russell R, Sondekoppam RV, et al. Consensus Practice Guidelines on Postdural Puncture Headache From a Multisociety, International Working Group: A Summary Report. JAMA Netw Open. 2023;6(8):e2325387.
  • Alatni RI, Alsamani R, Alqefari A. Treatment and Prevention of Post-dural Puncture Headaches: A Systematic Review. Cureus. 2024;16(1):e52330

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

April 1, 2026

Primary Completion (Estimated)

May 1, 2026

Study Completion (Estimated)

June 1, 2026

Study Registration Dates

First Submitted

March 26, 2026

First Submitted That Met QC Criteria

March 26, 2026

First Posted (Actual)

March 31, 2026

Study Record Updates

Last Update Posted (Actual)

April 7, 2026

Last Update Submitted That Met QC Criteria

April 1, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MG-260326

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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