Prediction of Cognitive Test Performance Using AI-Based Analysis of Narrative Speech

March 30, 2026 updated by: Chang Gung Memorial Hospital

This study aims to evaluate a new artificial intelligence (AI)-based method for measuring cognitive function using speech recordings. Participants will complete a short storytelling task in which they describe a story based on an image while their voice is recorded using a computer or mobile device.

The speech recordings will be analyzed using AI technology to identify patterns in speech that may be related to cognitive function. The system will then estimate scores that correspond to commonly used cognitive tests.

To evaluate the accuracy of this method, the AI-generated scores will be compared with results from standard cognitive assessments administered by trained researchers. These assessments may include tests commonly used to measure memory, attention, and other cognitive abilities.

The goal of this study is to determine whether speech analysis using AI can provide a convenient and efficient approach for cognitive assessment. If successful, this technology may help support early detection of cognitive decline and provide a practical tool for large-scale or remote cognitive screening.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

150

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Taiwan
      • Taoyuan District, Taiwan
        • Recruiting
        • Taoyuan
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  1. Age 50 years or older
  2. Able to communicate verbally and understand study instructions
  3. Able to hear and speak clearly
  4. Willing and able to provide written informed consent

Exclusion Criteria:

  1. Severe speech or hearing impairment
  2. History of major psychiatric disorders
  3. History of stroke, traumatic brain injury, Parkinson's disease, epilepsy, or other neurodegenerative diseases
  4. Current use of medications that may affect cognitive performance
  5. Unable to complete the study procedures due to severe attention deficits or agitation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Diagnostic
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: storytelling speech task
Participants will complete a storytelling speech task using a web-based platform followed by standardized cognitive assessments administered by trained research personnel.
Behavioral: AI-Based Storytelling Speech Assessment
Participants will be asked to describe a short story based on a randomly presented image while their speech is recorded using a web-based system on a computer or mobile device. The recorded speech will be analyzed using artificial intelligence algorithms to extract acoustic and linguistic features that may reflect cognitive function.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Correlation Between AI-Predicted Cognitive Scores and Standard Cognitive Assessment Scores
Time Frame: Immediately after completion of the study session
The correlation between cognitive scores predicted by the AI-based speech analysis system and scores obtained from clinician-administered cognitive assessments, including the Mini-Mental State Examination (MMSE) and the Wechsler Adult Intelligence Scale (WAIS).
Immediately after completion of the study session

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Chang Gung Memorial Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2025

Primary Completion (Estimated)

March 31, 2026

Study Completion (Estimated)

April 30, 2026

Study Registration Dates

First Submitted

March 30, 2026

First Submitted That Met QC Criteria

March 30, 2026

First Posted (Actual)

April 6, 2026

Study Record Updates

Last Update Posted (Actual)

April 6, 2026

Last Update Submitted That Met QC Criteria

March 30, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 202501155B0

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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