A Study of Uveitis in Children <18 Years of Age (UV1)

May 7, 2026 updated by: Jaeb Center for Health Research

The goal of this observational study is to collect data regarding clinical features and current/past treatments in children under 18 with uveitis. The main questions it aims to answer are:

  • What are the frequency of uveitis subtypes in children?
  • What are clinical and demographic characteristics overall and within each type of uveitis?

Participants will complete one enrollment visit with their doctor. Participants with uveitis onset <6 months from enrollment date will also partake in a 12 month chart review.

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

300

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • United States
    • Massachusetts
      • Boston, Massachusetts, United States, 02118
        • Recruiting
        • Department of Ophthalmology, Boston University School of Medicine
        • Contact:
    • Ohio
      • Akron, Ohio, United States, 44308
        • Recruiting
        • Akron Children's Hospital
        • Contact:
      • Cincinnati, Ohio, United States, 45229
        • Recruiting
        • Cincinnati Children's Hospital Medical Center
        • Contact:
      • Columbus, Ohio, United States, 43205
        • Recruiting
        • Pediatric Ophthalmology Associates, Inc.
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

Children <18 years with active or inactive uveitis.

Description

Inclusion Criteria:

  • Age:

    • Incident cases (onset ≤ 6 months) <17 years
    • Established cases (onset > 6 months) <18 years
  • Diagnosis of any type of uveitis (infectious or noninfectious) in any location except traumatic and post-operative uveitis.
  • Active or inactive uveitis with any treatment status (current / prior / none [but under surveillance]).

Exclusion Criteria:

  • Bilateral uveitis with differing etiologies
  • Traumatic uveitis
  • Post-operative uveitis
  • Immediate family member (spouse, biological or legal guardian, child, sibling, parent) who is an investigative site personnel directly affiliated with this study or who is an employee of JAEB Center for Health Research.
  • Ocular disease related to Retinoblastoma, Coat's disease, retinitis pigmentosa, inherited retinal degeneration, Juvenile xanthogranuloma (JXG), or leukemia/malignancy within the eye.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Children diagnosed with uveitis - established cases
Children diagnosed with uveitis (onset > 6 months), either active or inactive with or without current treatment at time of enrollment.
Children diagnosed with uveitis - incident cases
Children diagnosed with uveitis (onset ≤ 6 months), either active or inactive with or without current treatment at time of enrollment.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Frequency of uveitis subtypes in children <18 years of age
Time Frame: Enrollment
Enrollment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Jaeb Center for Health Research

Investigators

  • Study Chair: Kara C LaMattina, MD, Department of Ophthalmology, Boston University School of Medicine
  • Study Chair: Virginia Miraldi Utz, MD, Children's Hospital Medical Center, Cincinnati

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 14, 2026

Primary Completion (Estimated)

April 1, 2027

Study Completion (Estimated)

April 1, 2028

Study Registration Dates

First Submitted

April 1, 2026

First Submitted That Met QC Criteria

April 1, 2026

First Posted (Actual)

April 8, 2026

Study Record Updates

Last Update Posted (Actual)

May 8, 2026

Last Update Submitted That Met QC Criteria

May 7, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • UV1

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • ICF

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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