Clinical Performance of 3D-Printed Resin and Zirconia Implant Restorations

April 8, 2026 updated by: Mohammed El-Sawy, Menoufia University

Clinical Performance of 3D-Printed Resin Versus Milled Monolithic Zirconia in Implant-Supported Single Crowns and Short-Span Fixed Partial Dentures: A Randomized Controlled Clinical Trial

This randomized controlled clinical trial evaluates the clinical performance of 3D-printed resin restorations compared with milled monolithic zirconia in implant-supported single crowns and short-span fixed partial dentures (FPDs). A total of patients requiring one or two implant-supported restorations in the mandibular anterior region were randomly allocated to receive either 3D-printed permanent resin restorations (CROWNTEC) or conventionally milled zirconia prostheses.

All restorations were fabricated using a standardized digital workflow and assessed over a 12-month follow-up period. The primary outcome was restoration survival rate, while secondary outcomes included technical complications, peri-implant biological parameters, marginal bone level changes, and patient-reported satisfaction.

This study aims to provide clinical evidence regarding the viability of 3D-printed definitive resin materials as an alternative to zirconia in implant prosthodontics.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

This study was designed as a parallel-arm randomized controlled clinical trial to compare the clinical performance of implant-supported restorations fabricated using a novel 3D-printed resin material (CROWNTEC) with that of conventionally milled monolithic zirconia. The investigation focused on single crowns and short-span fixed partial dentures (FPDs) in the mandibular anterior region, where functional and esthetic demands are critical.

Participants meeting predefined inclusion criteria were randomly assigned into two intervention groups: a 3D-printed resin group and a zirconia group. All restorations were produced using a fully digital workflow, including intraoral scanning, CAD design, and standardized manufacturing protocols. Prostheses were delivered as either screw-retained or cement-retained restorations, with careful control of occlusion and prosthetic design parameters.

Patients were followed at baseline, 3, 6, and 12 months, with extended follow-up planned up to 24 months. The primary outcome measure was restoration survival, defined as the absence of failure requiring replacement. Secondary outcomes included technical complications such as fracture, chipping, and screw loosening; biological parameters including plaque index, bleeding on probing, and probing depth; and radiographic assessment of marginal bone level changes. Patient-reported outcomes were also evaluated using a visual analog scale to assess satisfaction with esthetics, comfort, and masticatory function.

By directly comparing a novel additive manufacturing material with an established reference standard, this study addresses a critical gap in the literature regarding the clinical applicability of 3D-printed definitive restorations in implant dentistry. The findings are expected to contribute valuable evidence on the performance, limitations, and potential role of 3D-printed resin materials in modern prosthodontic practice.

Study Type

Interventional

Enrollment (Estimated)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Participants must meet all of the following:
  • Age ≥18 years.
  • Have one or two osseointegrated dental implants requiring prosthetic restoration.
  • Demonstrate stable peri-implant tissues with no signs of inflammation or implant mobility.
  • Maintain good oral hygiene and controlled periodontal status.
  • Require either:
  • A single implant-supported crown, or
  • A short-span (maximum 3-unit) implant-supported fixed partial denture (FPD) supported by two implants in the mandibular anterior region.

Exclusion Criteria:

  • Participants are excluded if they have any of the following:
  • Severe parafunctional habits (e.g., bruxism).
  • Uncontrolled systemic diseases affecting bone metabolism or healing.
  • Peri-implantitis or compromised implant stability.
  • Requirement for cantilever prostheses or long-span restorations, or FPDs in areas other than the mandibular anterior region.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 3D-Printed Resin Restoration
Participants will receive implant-supported single crowns or short-span fixed partial dentures fabricated using 3D-printed permanent resin (CROWNTEC). Restorations are produced via a fully digital workflow, including intraoral scanning, CAD design, 3D printing, post-processing, and finishing, and delivered as screw- or cement-retained prostheses.
Device: 3D-Printed Resin Restoration (CROWNTEC)
Implant-supported single crowns or short-span fixed partial dentures fabricated using 3D-printed permanent resin (CROWNTEC). Restorations are produced using a standardized digital workflow, including intraoral scanning, CAD design, 3D printing at 50 µm layer thickness, post-processing (isopropyl alcohol cleaning, post-curing), finishing, and polishing. Restorations are delivered as screw- or cement-retained prostheses. In addition, Other participants will receive implant-supported single crowns or short-span fixed partial dentures fabricated from monolithic zirconia using CAD-CAM milling. Restorations undergo sintering, finishing, and polishing, and are delive
Other Names:
  • Milled Zirconia Restorations
Active Comparator: Milled Zirconia Restorations
Participants will receive implant-supported single crowns or short-span fixed partial dentures fabricated from monolithic zirconia using CAD-CAM milling. Restorations undergo sintering, finishing, and polishing, and are delivered as screw- or cement-retained prostheses.
Device: 3D-Printed Resin Restoration (CROWNTEC)
Implant-supported single crowns or short-span fixed partial dentures fabricated using 3D-printed permanent resin (CROWNTEC). Restorations are produced using a standardized digital workflow, including intraoral scanning, CAD design, 3D printing at 50 µm layer thickness, post-processing (isopropyl alcohol cleaning, post-curing), finishing, and polishing. Restorations are delivered as screw- or cement-retained prostheses. In addition, Other participants will receive implant-supported single crowns or short-span fixed partial dentures fabricated from monolithic zirconia using CAD-CAM milling. Restorations undergo sintering, finishing, and polishing, and are delive
Other Names:
  • Milled Zirconia Restorations

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Restoration Survival Rate
Time Frame: 12 months
The proportion of implant-supported single crowns and short-span fixed partial dentures that remain functional without fracture, loss, or need for replacement over the follow-up period. Survival is defined as the restoration remaining in situ, fully functional, and free of catastrophic failure requiring intervention.
12 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Menoufia University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

April 1, 2026

Primary Completion (Estimated)

April 1, 2027

Study Completion (Estimated)

November 1, 2028

Study Registration Dates

First Submitted

April 1, 2026

First Submitted That Met QC Criteria

April 8, 2026

First Posted (Actual)

April 13, 2026

Study Record Updates

Last Update Posted (Actual)

April 13, 2026

Last Update Submitted That Met QC Criteria

April 8, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

  • ADMNF-00326

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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