EMG ss AMG In Robotic/Laparoscopic Surgery (PEARL)

May 5, 2026 updated by: J. Ross Renew, M.D., Mayo Clinic

The Impact Of Electromyography Vs Acceleromyography On The Management Of Neuromuscular Block During Robotic And Laparoscopic Surgery: A Randomized Controlled Trial

The purpose of this study is to compare the mean cumulative weight-based/time-corrected rocuronium dose administered in patients undergoing robotic- or laparoscopic- assisted surgery using either acceleromyography or electromyography.

Study Overview

Status

Enrolling by invitation

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

400

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Florida
      • Jacksonville, Florida, United States, 32224
        • Mayo Clinic in Florida

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria

  • Age > or = 18 years old
  • Patients willing to participate and provide an integrated, informed consent
  • Patients undergoing elective laparoscopic- or robotic-assisted surgical procedures
  • Anticipated surgery duration < 300 minutes Exclusion Criteria
  • Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
  • Patients with systemic neuromuscular diseases such as myasthenia gravis.
  • Patients having surgery that would involve prepping the arm into the sterile field.
  • Patients with chronic kidney disease (eGFR <60).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: AMG
The anesthesia team will manage the level of block based on AMG values
Device: AMG device
The anesthesia team will use an AMG device to monitor neuromuscular block
Active Comparator: EMG
The anesthesia team will manage the level of block based on EMG values
Device: EMG
The anesthesia team will use an EMG device to monitor neuromuscular block

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cumulative rocuronium dose
Time Frame: Perioperative/Periprocedural
Weight- and time-adjusted mean cumulative rocuronium dose between the AMG and EMG groups
Perioperative/Periprocedural

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mean sugammadex dose
Time Frame: Perioperative/Periprocedural
Mean sugammadex dose between the two groups
Perioperative/Periprocedural
Number of rocuronium administrations
Time Frame: Perioperative/Periprocedural
Number of rocuronium administrations throughout the case,
Perioperative/Periprocedural
Frequency of placing a peripheral nerve stimulator
Time Frame: Perioperative/Periprocedural
Frequency of placing a peripheral nerve stimulator
Perioperative/Periprocedural
Depth of neuromuscular block prior to sugammadex administration
Time Frame: Perioperative/Periprocedural
Depth of neuromuscular block prior to sugammadex administration
Perioperative/Periprocedural

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mayo Clinic

Investigators

  • Principal Investigator: Johnathan Renew, Mayo Clinic

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

May 31, 2026

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Study Registration Dates

First Submitted

March 30, 2026

First Submitted That Met QC Criteria

April 6, 2026

First Posted (Actual)

April 13, 2026

Study Record Updates

Last Update Posted (Actual)

May 6, 2026

Last Update Submitted That Met QC Criteria

May 5, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

  • 25-014604

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

Yes

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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