Cross Modal Correlation of EEG and MRI Functional Connectivity: An Investigative Study

Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in Functional MRI. The primary aim of this study is to correlate correlation of MRI and EEG.

Study Overview

• Status: Recruiting
• Conditions: MRI, Functional MRI
• Intervention / Treatment: Diagnostic test: EEG

Detailed Description

Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in fMRI. The primary aim of this study is to correlate correlation of MRI and EEG. The expected study duration is approximately 24 months (first patient in to last patient out). Estimated Enrolment: 1500 Subjects.

The aim of this study is to correlate between fMRI and EEG. Overall, the integration of AI into the study of correlations between EEG and fMRI for brain network analysis holds great promise for advancing our understanding of brain function.

Upon consent, eligible participants will be invited for EEG evaluation. EEG will be obtained using a dry electrodes headset. Correlation between fMRI and EEG connectivity for each EEG frequency band across different configurations (brain atlas, EEG connectivity measure).

EEG data will undergo pre-processing of filtering, electrical line noise removal, artifact removal and down sampling. EEG analysis for each state, comprising within and between participant data, will include frequency analysis (peak frequency and relative power), oscillations (proportions of the activity of the alpha, beta, theta, and delta bands) and power spectra distribution. Functional connectivity analysis will be performed including functional coupling.

For evoked response potentials analysis, data will be segmented to trials/epochs. Bad trials will be excluded from analysis. Included trials data will be averaged. Event-related synchronization (ERS) / desynchronization (ERD) will be evaluated.

• Study Type: Interventional
• Enrollment (Estimated): 1500
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Shai Efrati, MD; Phone Number: 972509212866; Email: efratishai@outlook.com

Study Locations

• Israel
  • Zrifin, Israel, 70300
    • Recruiting
    • The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center (Assaf Harofeh)
    • Contact: Shai Efrati, Prof; Phone Number: 972-8-9779393; Email: efratishai@outlook.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Male or females aged 18 years or older.
• Performed a brain MRI at the Sagol Center MRI Unit, at the Shamir Medical Center
• Able to cooperate in an EEG evaluation
• Can read and sign the informed consent.

Exclusion Criteria:

• Any scalp/bone abnormality incompatible with the EEG electrodes
• Any known allergy to metals.
• Inability to cooperate with simple instructions.
• Inability to read and sign the informed consent.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Electroencephalography (EEG); EEG excels in capturing rapid changes in neural activity, making it ideal for investigating the dynamic nature of brain networks. It can detect millisecond-level fluctuations in electrical brain signals, allowing precise timing of neural events and interactions between brain regions.	Diagnostic test: EEG; EEG uses small sensors paced on the scalp to record the brain's electrical activity.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Correlation of fMRI and EEG functional connectivity.	Examines how brain connectivity patterns measured by fMRI (blood-flow activity) relate to connectivity patterns measured by EEG (electrical activity).	The expected study duration is approximately 24 months (first patient in to last patient out)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Correlation between EEG to anatomical MRI findings	Investigates how electrical brain activity (EEG) corresponds to structural brain features or abnormalities seen on anatomical MRI.	The expected study duration is approximately 24 months (first patient in to last patient out)
Correlation between EEG to clinical diagnosis, cognitive and physical parameters.	Explores how EEG findings relate to a patient's medical diagnosis, cognitive functioning (e.g., memory, attention), and physical/neurological condition.	The expected study duration is approximately 24 months (first patient in to last patient out)

Collaborators and Investigators

• Sponsor: Assaf-Harofeh Medical Center
• Investigators: Principal Investigator: Shai Efrati, MD, Study Principal Investigator

Study record dates

Study Major Dates

• Study Start (Actual): April 2, 2024
• Primary Completion (Estimated): January 31, 2030
• Study Completion (Estimated): January 31, 2030

Study Registration Dates

• First Submitted: February 25, 2026
• First Submitted That Met QC Criteria: April 16, 2026
• First Posted (Actual): April 20, 2026

Study Record Updates

• Last Update Posted (Actual): April 22, 2026
• Last Update Submitted That Met QC Criteria: April 20, 2026
• Last Verified: April 1, 2026

More Information

Terms related to this study

• Keywords: EEG; Fmri
• Additional Relevant MeSH Terms: Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Neurological; Electrodiagnosis; Electroencephalography
• Other Study ID Numbers: 0287-23-ASF

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No