Évaluation de l'Impact du Compressed Sensing Sur le Signal QSM (CS-QSM)

Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which a maximum of four additional 25-minute sequences will be added.

MRI of routine care includes at least the following sequences:

• 3D T1 TFE (2 minutes)
• T2 TSE (2 minutes)
• 3D FLAIR (3 minutes)

The sequences added by the research lasting 25 minutes are:

• SWI QSM 1.0iso 8 echoes (10 minutes)
• SWI QSM 1.0iso 8 echoes CS 6 (7 minutes)
• SWI QSM 1.0iso 8 echoes CS 9 (5 minutes)
• SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)

Study Overview

• Status: Completed
• Conditions: MRI
• Intervention / Treatment: Device: MRI

Detailed Description

Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which a maximum of four additional 25-minute sequences will be added.

MRI of routine care includes at least the following sequences:

• 3D T1 TFE (2 minutes)
• T2 TSE (2 minutes)
• 3D FLAIR (3 minutes)

The sequences added by the research lasting 25 minutes are:

• SWI QSM 1.0iso 8 echoes (10 minutes)
• SWI QSM 1.0iso 8 echoes CS 6 (7 minutes)
• SWI QSM 1.0iso 8 echoes CS 9 (5 minutes)
• SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)

• Study Type: Observational
• Enrollment (Actual): 82

Contacts and Locations

Study Locations

• France
  • Paris
    • Paris, Paris, France, 75019
      • Hhopital fondation adolphe de rothschild

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Two groups of patients will be included as part of this research protocol:

• Group I: Patients with MS
• Group II: Patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS pathology, age and gender matched with group I.

Description

Inclusion Criteria:

For patients with MS:

• Patient over 18 years old
• Presenting MS defined according to McDonald's revised criteria for spatial and temporal clinical or radiological dissemination [16],
• Should benefit as part of the care of an MRI examination with or without injection of gadolinium
• Express consent to participate in the study
• Affiliate or beneficiary of a social security scheme

For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease:

• Patient over 18 years old
• Should benefit as part of the care of an MRI examination with or without injection of gadolinium
• Express consent to participate in the study
• Affiliate or beneficiary of a social security scheme

Exclusion Criteria:

• For patients with MS:
• Patient benefiting from a legal protection measure
• Pregnant or breastfeeding woman

For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease:

• Patient benefiting from a legal protection measure
• Pregnant or breastfeeding woman
• Patient with inflammatory and / or demyelinating pathology of the CNS

Secondary exclusion criteria :

• Motion artefact not allowing interpretation of images
• Patient who did not perform one of the following sequences: 3D T1 TFE, 3D FLAIR (for MS patients), SWI QSM 1.0iso 8 echoes.

Secondarily excluded patients will be replaced.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
SEP; With Multiple Sclerosis as defined by McDonald's revised clinical or radiological spatial and temporal dissemination criteria	Device: MRI; MRI of routine care includes at least the following sequences: 3D T1 TFE (2 minutes); T2 TSE (2 minutes); 3D FLAIR (3 minutes) The sequences added by the research lasting 25 minutes are: SWI QSM 1.0iso 8 echoes (10 minutes); SWI QSM 1.0iso 8 echoes CS 6 (7 minutes); SWI QSM 1.0iso 8 echoes CS 9 (5 minutes); SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)
NO SEP; For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease	Device: MRI; MRI of routine care includes at least the following sequences: 3D T1 TFE (2 minutes); T2 TSE (2 minutes); 3D FLAIR (3 minutes) The sequences added by the research lasting 25 minutes are: SWI QSM 1.0iso 8 echoes (10 minutes); SWI QSM 1.0iso 8 echoes CS 6 (7 minutes); SWI QSM 1.0iso 8 echoes CS 9 (5 minutes); SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
concordance of QSM signal with and without compressed-sensing in white matter	concordance of QSM signal with and without compressed-sensing in white matter	1 DAY

Collaborators and Investigators

• Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Study record dates

Study Major Dates

• Study Start (Actual): December 15, 2021
• Primary Completion (Actual): May 14, 2025
• Study Completion (Actual): May 14, 2025

Study Registration Dates

• First Submitted: May 25, 2021
• First Submitted That Met QC Criteria: May 25, 2021
• First Posted (Actual): May 28, 2021

Study Record Updates

• Last Update Posted (Actual): January 5, 2026
• Last Update Submitted That Met QC Criteria: December 30, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: JSY_2021_13

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No