Association Between Microplastic Exposure and the Pathological Progression of Gastric Carcinogenesis

April 25, 2026 updated by: Yongquan Shi

Association of Microplastic Exposure With Pathological Stages of Gastric Mucosal Carcinogenesis: A Cross-Sectional Study

The objective of this clinical trial is to explore the correlation between the level of microplastic exposure and the risk of gastric mucosal carcinogenesis, and to evaluate the strength of its effect as an independent risk factor. The main questions it aims to answer include: Does the level of microplastic exposure increase the risk of gastric mucosal carcinogenesis? Can the correlation between the level of microplastic exposure and gastric mucosal carcinogenesis, as well as the sources of high - risk microplastic exposure, be explored through a questionnaire on external microplastic exposure? Researchers will complete a design structured questionnaire and ask participants to fill it out carefully and truthfully to determine whether the level of microplastic exposure increases the risk of gastric mucosal carcinogenesis.

Study Overview

Status

Recruiting

Conditions

Detailed Description

The study will categorize participants into three groups based on endoscopic and/or histopathological findings: chronic non-atrophic gastritis, precancerous lesions, and gastric cancer. Basic demographic information, *Helicobacter pylori* infection status, and plastic exposure assessment scores will be recorded for each group.

Study Type

Observational

Enrollment (Estimated)

450

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
    • Shaanxi
      • Xi'an, Shaanxi, China, 710032
        • Recruiting
        • Xijing Hosipital of Digestive Disease

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients were enrolled from a single center, Xijing Hospital.

Description

Inclusion Criteria:

  • Aged between 18 and 75 years old, gender is not restricted
  • Having a clear diagnosis result within the recent three months and being diagnosed with chronic non - atrophic gastritis, precancerous lesions of gastric cancer, or gastric cancer for the first time
  • Have clear Helicobacter pylori (Hp) test results
  • Be in normal mental state and able to independently complete the questionnaire survey

Exclusion Criteria:

  • Patients with a history of malignant tumors in other parts
  • Patients who have previously undergone upper gastrointestinal surgery, chemotherapy, or radiotherapy
  • Patients with severe diseases of major organs such as the heart, lungs liver, and kidneys
  • Patients who are currently receiving psychological intervention or taking psychiatric drugs
  • Pregnant or lactating women
  • Patients with severe missing clinical data or questionnaire information
  • Refusing to sign the informed consent form

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Chronic non-atrophic gastritis
Patients diagnosed with chronic non-atrophic gastritis based on endoscopic and/or histopathological results
precancerous lesion
Patients with chronic atrophic gastritis, gastric intestinal metaplasia, and gastric intraepithelial neoplasia based on endoscopic and/or histopathological results
gastric cancer
patients with gastric cancer according to endoscopic and/or histopathological results

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Correlation between external exposure levels of microplastics and three pathological stages of gastric mucosal carcinogenesis
Time Frame: 9 months
The investigators evaluated the correlation between external exposure to microplastics and the three pathological stages of gastric mucosal carcinogenesis based on the patients' final diagnosis results and the completed questionnaires they filled out.
9 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Analysis of sources of high - risk microplastic exposure
Time Frame: 9 months
Analyze the sources of high-risk microplastic exposure by comparing the scores of each item in the questionnaires of the three groups of participants.
9 months
Synergistic toxicity of microplastics and Helicobacter pylori
Time Frame: 9 months
Analyze whether microplastics synergistically promote gastric mucosal injury and increase the risk of canceration with Helicobacter pylori through interaction.
9 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Yongquan Shi

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 31, 2026

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Study Registration Dates

First Submitted

April 14, 2026

First Submitted That Met QC Criteria

April 14, 2026

First Posted (Actual)

April 21, 2026

Study Record Updates

Last Update Posted (Actual)

April 30, 2026

Last Update Submitted That Met QC Criteria

April 25, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • KY20262104-F-1

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Gastric Carcinoma

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Gabon

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe