Dynamic Functional Imaging Phenotyping and Disease Progression Risk Assessment in COPD Using Dynamic Chest Radiography: A Multicenter Retrospective Study

To evaluate the utility of DCR-derived parameters for identifying dynamic functional imaging phenotypes, assessing disease severity, and predicting the risk of disease progression in COPD.

Study Overview

• Status: Recruiting
• Conditions: Chronic Obstructive Pulmonary Disease

Detailed Description

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Approximately 100 million people in China have COPD, yet the early diagnosis rate remains below 13%. This multicenter retrospective study will collect previously acquired dynamic chest radiography (DCR) images, pulmonary function test results, chest computed tomography images, symptom scores, clinical data, and follow-up outcomes from participating centers. A standardized multicenter retrospective DCR-COPD database will be established to systematically evaluate the utility of DCR-derived parameters for characterizing dynamic functional imaging phenotypes, assessing disease severity, and predicting the risk of COPD progression. The study will also provide a foundation for model development and subsequent prospective multicenter validation.

• Study Type: Observational
• Enrollment (Estimated): 2500

Contacts and Locations

• Study Contact: Name: Laiyu Liu, Professor; Phone Number: +86 13632102245; Email: liulaiyu@sina.com
• Study Contact Backup: Name: Dong Yu; Phone Number: +86 15625868995; Email: 15625868995@163.com

Study Locations

• China
  • Guangdong
    • Guangzhou, Guangdong, China, 510400
      • Recruiting
      • Nanfang Hospital, Southern Medical University
      • Contact: Laiyu Liu, Professor; Phone Number: +86 13632102245; Email: liulaiyu@sina.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by chronic respiratory symptoms, including dyspnea, cough, and sputum production. These symptoms result from airway abnormalities, such as bronchitis or bronchiolitis, and/or alveolar abnormalities, such as emphysema, that cause persistent and often progressive airflow obstruction.

Description

Inclusion Criteria:

1. Aged 30-85 years.
2. Male or female.
3. Patients who underwent pulmonary function testing and dynamic chest radiography at the hospital.

Exclusion Criteria:

1. Incomplete medical records.
2. Considered unsuitable for inclusion in the study at the investigator's discretion.

Study Plan

How is the study designed?

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort
COPD group; any patient who complains of dyspnea, chronic cough or sputum, a history of recurrent lower respiratory infection and/or a history of exposure to disease risk factors, Pulmonary function examination indicated that FEV1/FVC <0.7 after bronchodilator was used to confirm COPD.
PRISM group; After bronchial dilation, FEV1/FVC was ≥0.70, and FEV1%PRED was <80%.
Smoking exposure groups; Smoking history of 10 years, or without COPD, pulmonary function of COPD diagnosis standard.
Normal control group; Never-smokers without airflow limitation and with normal pulmonary function.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Exacerbation/respiratory history and event	Measurement of disease control and burden	At Baseline
FEV1 %	Measurement of lung function	At Baseline
FEV1 /FVC	Measurement of lung function	At Baseline
Emphysema	Measurement of chest CT	At Baseline
diaphragm movement	Measurement of Dynamic chest radiograph	At Baseline
lung field area	Measurement of Dynamic chest radiograph	At Baseline
lung field area change rate	Measurement of Dynamic chest radiograph	At Baseline
CAT	Measurement of questionnaires	At Baseline
SGRQ	Measurement of questionnaires	At Baseline
mMRC	Measurement of questionnaires	At Baseline
Smoking history and status	Risk factors of COPD development or lung function decline	At Baseline

Collaborators and Investigators

• Sponsor: Nanfang Hospital, Southern Medical University
• Collaborators: The First Affiliated Hospital of Guangzhou Medical University; Qingyuan People's Hospital
• Investigators: Study Chair: Laiyu Liu, professor, Nanfang Hospital, Southern Medical University

Study record dates

Study Major Dates

• Study Start (Actual): August 3, 2026
• Primary Completion (Estimated): December 30, 2029
• Study Completion (Estimated): January 30, 2030

Study Registration Dates

• First Submitted: August 9, 2026
• First Submitted That Met QC Criteria: August 9, 2026
• First Posted (Actual): August 13, 2026

Study Record Updates

• Last Update Posted (Actual): August 13, 2026
• Last Update Submitted That Met QC Criteria: August 9, 2026
• Last Verified: August 1, 2026

More Information

Terms related to this study

• Keywords: Chronic obstructive pulmonary disease; Dynamic Chest Radiography
• Additional Relevant MeSH Terms: Pathologic Processes; Chronic Disease; Disease Attributes; Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive; Pathological Conditions, Signs and Symptoms; Pulmonary Disease, Chronic Obstructive
• Other Study ID Numbers: NFEC-2026-570; 2025CR003 (Other Grant/Funding Number: Clinical Research Program of Nanfang Hospital, Southern Medical University)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No