Research on the Application of Sigma Radiopharmaceutical FBFP in Cerebral Stroke

Inclusion Criteria:

1. Angiography diagnosis shows unilateral anterior circulation head and neck artery stenosis with a diameter reduction of>70%, and there is no stenosis in the contralateral anterior circulation or bilateral posterior circulation with a diameter reduction of>50%;
2. Transient ischemic attack or ischemic stroke that must have occurred within the past 12 months in the affected vascular area, with the most recent attack lasting more than 3 weeks;
3. MRI shows no new intracranial infarction lesions;
4. No previous infarction lesions in the pontine area;
5. Either PET/MR blood flow or metabolic imaging shows reduced blood flow and metabolism in the affected hemisphere, with a reduction rate exceeding 10% compared to the contralateral region;
6. Subjects and informants can complete relevant examinations and follow-up work;
7. The subject or their authorized representative signs the informed consent form.

Exclusion Criteria:

1. Poor image quality due to head movement and other reasons during the scanning process.
2. There are other neurological disorders that can cause brain dysfunction, such as depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, traumatic brain injury, normal intracranial pressure hydrocephalus, etc.
3. There are other systemic diseases that can cause cognitive impairment, such as liver dysfunction, kidney dysfunction, thyroid dysfunction, severe anemia, folate and vitamin B12 deficiency, special infections (such as syphilis, HIV), alcohol and drug abuse, etc.
4. Existence of mental and neurological developmental delay.
5. There are other known diseases that may cause cognitive impairment.
6. Individuals with severe visual and hearing impairments, claustrophobia, and other conditions who cannot cooperate with MRI examinations.
7. Suffering from diseases that prevent cooperation in completing cognitive examinations.
8. Refusal to sign informed consent form during baseline period -