Benefit of SeptiFast Multiplex PCR in the Etiologic Diagnosis and Therapeutic Approach for Onco-hematology Patients Presenting Sepsis (SEPTIFAST)

Inclusion Criteria:

All patients with onco-hematologic or cancerous pathology, or hematologic disease with chemotherapy and/or radiotherapy and/or some other immunosuppressant treatment in progress presenting an infection requiring hospitalisation and meeting the following criteria:

• Sepsis (at least one of the following signs):

  • Fever > 38.2°C or hypothermia < 36°C
  • FO120 min
  • PA<120 mmHg (or 50 mmHg reduction in base numbers)
  • Respiratory F > 30/min
  • Confusion
  • Hyperleucocytosis (>12 G/l) or leucopenia (<4 G/l)
  • C-Reactive protein > 40

• With or without organ dysfunction as defined by :

  • Hypoxia (PaO2/FiO2<300mmHg)
  • Oliguria (urine deficiency<0.5 ml/kg/h in probed patient)
  • Creatinine > 200umol/l
  • INR>1.5 or TCA>2 X control in the absence of anticoagulant treatment
  • Platelets < 100 G/l
  • Bilirubin > 35 umol/l
  • Lactatemia > 2 mmol/l
  • Arterial hypotension (PAS<90mmHg, or PAM<70mmHg or reduction of more than 40 mmHG if known hypertension)

Exclusion Criteria:

• Minor patient
• Pregnancy
• A patient cannot be included again within 15 days of his/her preceding inclusion