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Mushroom Blend on Oxygen Kinetics

3. december 2014 opdateret af: University of North Carolina, Chapel Hill

Acute Effects of a Mushroom Blend on Oxygen Kinetics, Aerobic Power and Time to Fatigue

Purpose: To determine the acute effects of a mushroom blend vs. placebo on oxygen kinetics, aerobic power and time to fatigue in healthy adults.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Participants: Twenty-eight, healthy, active, recreationally-trained adults ages 18-35.

Procedures (methods): All subjects will report to the Applied Physiology Laboratory in Fetzer Rm 025 for phase I of the study for a total of 7 visits. A randomly selected subset of 8 participants will continue to phase II, and return to the lab for an additional 3 visits to evaluate feasibility. Visit 1 will consist of a physical, enrollment and consenting. Visits, 2, 3, and 4 will be separated by a minimum of 24 hours. During visit 2, participants will perform a maximal oxygen consumption (VO2max) test on a cycle ergometer. During visit 3 participants will be asked to complete a 6-minute oxygen kinetics test on a cycle ergometer; lactate threshold and oxygen saturation will be measured at baseline, minutes 2, 3 and 6 during the 6 min ride. During visit 4, participants will perform a 3-minute critical power (CP) test and will provide a saliva sample, to be measured for cortisol levels, immediately prior to and after the CP test. Following visit 4, participants will be randomly assigned, in a double-blind fashion, to either a placebo or mushroom blend treatment group. Participants in the placebo and treatment groups will be asked to consume 2 servings, 3 times daily for 7 days. Following supplementation, participants will return to the laboratory for visits 5-7, each of which will be separated by a minimum of 24 hours. The same protocol performed during visits 2-4 will be repeated in the same order for visits 5-7; the VO 2max test, the 6 min oxygen kinetics test, and the CP test with a pre and post saliva sample. The randomly selected subset of 8 participants will continue into phase II (n=4 for treatment; n=4 for placebo). During phase II, the 8 participants in the placebo and treatment groups will be asked to consume 2 servings, 3 times daily for 14 additional days to determine feasibility of a longer supplementation phase. Following supplementation, the same protocol performed during visits 2-4 will be repeated in the same order for visits 8-10, each of which will be separated by a minimum of 24 hours.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

28

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • North Carolina
      • Chapel Hill, North Carolina, Forenede Stater, 27599
        • Applied Physiology Laboratory, Fetzer Hall

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 35 år (Voksen)

Tager imod sunde frivillige

Ja

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  • Participant has been involved in exercise program for a minimum of one year prior to recruitment (≥ 3 d/wk)
  • Participant is able to exercise (i.e. no existing musculoskeletal injury)
  • Participant is willing and able to comply with the protocol
  • Participant is apparently healthy and free from disease, as determined by a health history questionnaire and physical
  • Participant agrees to abstain from smoking, caffeine, tobacco, and alcohol before testing days
  • Participant agrees to abstain from exercise 24 hours prior to each testing visit
  • Participant is not allergic to mushrooms

Exclusion Criteria:

  • Participant has a BMI ≤ 28 kg/m² (pre-screening inclusion)
  • Having a history of medical or surgical events that may significantly affect the study outcome, including cardiovascular disease, metabolic, renal, hepatic, or musculoskeletal disorders
  • Participant is using, or has used one of the following dietary supplements within 12 weeks prior to enrollment: Beta-alanine, Creatine, Carnosine or Taurine
  • Participant has lost or gained greater than ten pounds within the previous 3 month
  • Participant is currently enrolled in another clinical trial.
  • Participant has a known allergy or sensitivity to any ingredient in the test product or placebo (determined from health history questionnaire)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Dobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Aktiv komparator: Mushroom Blend
4 grams daily; oral; 7 and 21 days
Kosttilskud: Mushroom Blend
Scivation
Andre navne:
  • Cordyceps
Placebo komparator: Placebo
4 grams maltodextrin, oral, 7 and 21 days
Kosttilskud: Placebo

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Oxygen kinetics
Tidsramme: during a 6 min
oxygen uptake and utilization using indirect calorimetry during a 6 min steady-state exercise bout
during a 6 min
Critical Power
Tidsramme: during a 3 min
3 min all-out cycling test to measure anaerobic and aerobic performance
during a 3 min

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Lactate
Tidsramme: baseline, 2min, 3min, 6min (pre-post supplementation)
baseline, 2min, 3min, 6min (pre-post supplementation)
Cortisol
Tidsramme: during a 6 min
during a 6 min
Maximal Oxygen Consumption
Tidsramme: during a graded exercise test to exhaustion
oxygen consumption and utilization using indirect calorimetry during a graded exercise test
during a graded exercise test to exhaustion

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

University of North Carolina, Chapel Hill

Samarbejdspartnere

Scivation, Inc

Efterforskere

  • Ledende efterforsker: Abbie Smith-Ryan, PhD, University of North Carolina

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. august 2014

Primær færdiggørelse (Faktiske)

1. december 2014

Studieafslutning (Faktiske)

1. december 2014

Datoer for studieregistrering

Først indsendt

27. februar 2014

Først indsendt, der opfyldte QC-kriterier

28. februar 2014

Først opslået (Skøn)

3. marts 2014

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

4. december 2014

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

3. december 2014

Sidst verificeret

1. august 2014

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Andre undersøgelses-id-numre

  • 14-0062

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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Kosttilskud

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Placeringer

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