T1D Risk Assessment in Kids With Relatives (TRAKR)

Inclusion Criteria:

1. Mother and/or father with type 1 diabetes

   • age > 18 years
   • type 1 diabetes : insulin-dependent diabetes positive for autoantibodies against insulin and/or GAD and/or IA-2 and/or ZnT8 at the time of diagnosis
   • planning to give birth or having given birth since less than 8 months
   • agreeing to participate upon written informed consent
   • covered by the French social security system

2. Mother/father without Type 1 diabetes

   • age > 18 years old
   • with a spouse with type 1 diabetes : insulin-dependent diabetes positive for autoantibodies against insulin and/or GAD and/or IA-2 and/or ZnT8 at the time of diagnosis
   • planning to give birth or having given birth since less than 8 months
   • agreeing to participate upon written informed consent
   • covered by the French social security system

3. Children born to mother and/or father with type 1 diabetes

   • age < 8 months
   • with at least one parent with T1D
   • with both parents agreeing to participate
   • both parents covered by the French social security system

Exclusion Criteria:

1) Mother/father

• secondary forms of diabetes

• monogenic forms of diabetes

  1 or 2) For the mother

• malignant neoplastic or psychiatric disease

  3 ) Newborns of mother/father with type 1 diabetes

• Severe foetal disease
• Severe congenital malformation
• Congenital measles