Evaluation of Inflammatory Markers and Periodontal Viruses on Periodontitis Patients With CAD

Evaluation of Demographic Variables, Clinical Parameters, Inflammatory Markers and Viruses in Periodontitis Patients With Coronary Artery Diseases

Patrocinadores

Patrocinador principal: Meenakshi Ammal Dental College and Hospital

Fuente Meenakshi Ammal Dental College and Hospital
Resumen breve

To assess and compare the demographic variables, periodontal parameters, cardiac parameters and the expression of periodontal viruses (CMV, HSV and EBV) and inflammatory biomarkers(PTX-3, TLR-2 & TLR-4) in periodontally healthy and generalized periodontitis patients with and without coronary artery disease(CAD).

Descripción detallada

A total of 240 subjects will be recruited based on the power of the study. The selected subjects will be divided into four groups based on the inclusion and exclusion criteria.

1. GROUP I: 60 healthy subjects ( No generalised periodontitis and no CAD)

2. GROUP II: 60 generalised periodontitis subjects without CAD

3. GROUP III: 60 CAD subjects without generalised periodontitis

4. GROUP IV: 60 subjects with Generalised periodontitis and CAD

Sub-gingival plaque samples will be collected from the subjects of all the four groups. Coronary artery plaque samples will be collected from the patients who were indicated for coronary artery bypass graft surgery (CABG) among group III and group IV.

The demographic variables , periodontal parameters , cardiac parameters , expression of periodontal viruses and inflammatory biomarkers will be measured in all four groups ,

Estado general Active, not recruiting
Fecha de inicio November 15, 2018
Fecha de Terminación December 1, 2020
Fecha de finalización primaria July 1, 2020
Tipo de estudio Observational
Resultado primario
Medida Periodo de tiempo
Periodontal Virus and Inflammatory Markers expression in periodontitis patients with coronary artery disease 2 years
Inscripción 240
Condición
Intervención

Tipo de intervención: Diagnostic Test

Nombre de intervención: Molecular analysis

Descripción: RT- PCR

Elegibilidad

Método de muestreo: Non-Probability Sample

Criterios:

Inclusion Criteria:

1. Patients willing to participate in the study.

2. Patients with 30 to 65 years of age group

3. Both genders

4. Patients should have minimum of 10 natural teeth.

5. In case of group III and IV patients with coronary heart disease to be included.

Exclusion Criteria

1. Patients who had undergone periodontal therapy within the previous 6 months.

2. Type I and II Diabetes mellitus

3. Sarcoidosis patients.

4. Carcinoma patients.

5. Rheumatic arthritis patients.

6. Tuberculosis patients.

7. Immunosuppressive conditions.

8. Patients with other inflammatory diseases.

Género: All

Edad mínima: 30 Years

Edad máxima: 65 Years

Voluntarios Saludables: Accepts Healthy Volunteers

Oficial general
Apellido Papel Afiliación
Jaideep Mahendra, PhD Principal Investigator MeenakshiAmmal Dental College & Hospital
Ubicación
Instalaciones: MeenakshiAmmal Dental College and Hospital
Ubicacion Paises

India

Fecha de verificación

February 2020

Fiesta responsable

Tipo: Principal Investigator

Afiliación del investigador: Meenakshi Ammal Dental College and Hospital

Nombre completo del investigador: Dr.Jaideep Mahendra

Título del investigador: Professor and Director of PG studies

Palabras clave
Tiene acceso ampliado No
Condición Examinar
Grupo de brazo

Etiqueta: Group I

Descripción: Healthy group ( No generalised periodontitis and no CAD)

Etiqueta: Group II

Descripción: Generalised periodontitis patients without CAD

Etiqueta: Group III

Descripción: CAD patients without generalised periodontitis

Etiqueta: Group IV

Descripción: Generalised periodontitis with CAD

Datos del paciente No
Información de diseño del estudio

Modelo de observación: Case-Control

Perspectiva de tiempo: Cross-Sectional

Fuente: ClinicalTrials.gov